Objective: To discuss the altered pharmacokinetic properties of selected antibiotics in
critically ill patients and to develop basic dose adjustment principles for this patient …

Intermittent intravenous administration of antibiotics is the first-line approach in the
management of severe infections worldwide. However, the potential benefits of alternate …

Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to
hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic …

Objective: To describe a pharmacokinetic model of piperacillin concentrations in plasma and
subcutaneous tissue when administered by bolus dosing and continuous infusion in …

Piperacillin–tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad
spectrum of antibacterial activity that includes Gram-positive and-negative aerobic and …

The purpose of this randomized, multicenter, open-label study was to compare the
continuous infusion of piperacillin-tazobactam with the standard intermittent infusion in 262 …

The standard mode of administration of piperacillin treatment is by intermittent infusion.
However, continuous infusion may be advantageous as β-lactam antibiotics exhibit time …

Background Intravenous broad–spectrum antibiotics are indicated for the treatment of
severe infections. However, the emergence of infections caused by multiple‐drug resistant …

Killing of bacteria by β-lactam antibiotics is maximal at around four times the minimum
inhibitory concentration in vitro. To ensure an optimal effect when treating severe infections …

Objectives: We investigated the population pharmacokinetics and pharmacodynamics of
piperacillin and tazobactam in hospitalized patients. Patients and methods: A multicentre …