Metabolites produced by the host and microbiota play a crucial role in how human bodies
develop and remain healthy. Most of these metabolites are produced by microbiota and …

ABSTRACT Avian Pathogenic E. coli (APEC) is the causative agent of avian colibacillosis,
resulting in economic losses to the poultry industry through morbidity, mortality and carcass …

Antiviral drugs are used globally as treatment and prophylaxis for long-term and acute viral
infections. Even though antivirals also have been shown to have off-target effects on …

Pathogenic bacteria possess a remarkable ability to adapt to fluctuating host environments
and cause infection. Disturbing bacterial central metabolism through inhibition of 1-deoxy-d …

Virulence and metabolism are often interlinked to control the expression of essential
colonisation factors in response to host-associated signals. Here, we identified an …

Some Escherichia coli strains harbour the pks island, a 54 kb genomic island encoding the
biosynthesis genes for a genotoxic compound named colibactin. In eukaryotic cells …

The obligate intracellular bacterium, Chlamydia trachomatis, has evolved to depend on its
human host for many metabolites, including most amino acids and three of the four …

Avian pathogenic E. coli (APEC) are the causative agent for extraintestinal infections in
poultry birds. APEC infections in poultry birds produce diverse array of lesions from localized …

While evolution proceeds through the generation of random variant alleles, the application
of selective pressures can select for subsets of mutations that confer fitness-improving …

Phenotypic and genetic heterogeneities are conserved features of prokaryotic populations.
During periods of stress, this programmed diversity increases the likelihood that variants …