Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers

HM Dunnenberger, KR Crews… - Annual review of …, 2015 - annualreviews.org
Although the field of pharmacogenetics has existed for decades, practioners have been slow
to implement pharmacogenetic testing in clinical care. Numerous publications describe the …

Clinical implementation of pharmacogenomics for personalized precision medicine: barriers and solutions

ME Klein, MM Parvez, JG Shin - Journal of pharmaceutical sciences, 2017 - Elsevier
Clinical implementation of pharmacogenomics (PGx) leads to personalized medicine, which
improves the efficacy, safety, and cost-effectiveness of treatments. Although PGx-based …

Pharmacogenomic knowledge gaps and educational resource needs among physicians in selected specialties

KA Johansen Taber, BD Dickinson - … and personalized medicine, 2014 - Taylor & Francis
Background The use of pharmacogenomic testing in the clinical setting has the potential to
improve the safety and effectiveness of drug therapy, yet studies have revealed that …

Oncologists' and cancer patients' views on whole-exome sequencing and incidental findings: results from the CanSeq study

SW Gray, ER Park, J Najita, Y Martins, L Traeger… - Genetics in …, 2016 - nature.com
Purpose: Although targeted sequencing improves outcomes for many cancer patients, it
remains uncertain how somatic and germ-line whole-exome sequencing (WES) will …

Implementation of a multidisciplinary pharmacogenomics clinic in a community health system

HM Dunnenberger, M Biszewski, GC Bell… - American Journal of …, 2016 - academic.oup.com
Purpose The development and implementation of a multidisciplinary pharmacogenomics
clinic within the framework of an established community-based medical genetics program …

Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome

AM Schijvens, R Ter Heine, SN de Wildt… - Pediatric …, 2019 - Springer
Nephrotic syndrome is one of the most common glomerular disorders in childhood.
Glucocorticoids have been the cornerstone of the treatment of childhood nephrotic …

Inconsistency in race and ethnic classification in pharmacogenetics studies and its potential clinical implications

F Zhang, J Finkelstein - Pharmacogenomics and personalized …, 2019 - Taylor & Francis
Introduction Racial and ethnic categories are frequently used in pharmacogenetics literature
to stratify patients; however, these categories can be inconsistent across different studies. To …

Assessment of the implementation of pharmacogenomic testing in a pediatric tertiary care setting

I Cohn, R Manshaei, E Liston, JBA Okello… - JAMA network …, 2021 - jamanetwork.com
Importance Pharmacogenomic (PGx) testing provides preemptive pharmacotherapeutic
guidance regarding the lack of therapeutic benefit or adverse drug reactions of PGx targeted …

Pharmacists leading the way to precision medicine: updates to the core pharmacist competencies in genomics

RS Gammal, YM Lee, NJ Petry, O Iwuchukwu… - American Journal of …, 2022 - Elsevier
Genomics is becoming an increasingly important part of health care, and pharmacists are
well-positioned to be practice-based leaders in pharmacogenomics and precision medicine …

[HTML][HTML] Pharmacogenetics: an important part of drug development with a focus on its application

JT Oates, D Lopez - International journal of biomedical …, 2018 - ncbi.nlm.nih.gov
Since the human genome project in 2003, the view of personalized medicine to improve
diagnosis and cure diseases at the molecular level became more real. Sequencing the …