Summary Protein homeostasis, or" proteostasis," is indispensable for a balanced, healthy
environment within the cell. However, when natural proteostasis mechanisms are …

Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities,
have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling …

Probiotic lactic acid bacteria (LAB) are a particular group of gram-positive bacteria that are
usually involved in natural ferments and widely used in food manufacture industry. Most of …

Cancer cells are characterized by an increase in the rate of reactive oxygen species (ROS)
production and an altered redox environment compared to normal cells. Furthermore, redox …

CD44 is an adhesion molecule expressed in cancer stem-like cells. Here, we show that a
CD44 variant (CD44v) interacts with xCT, a glutamate-cystine transporter, and controls the …

Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …

Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK)
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …

Aged and degenerated intervertebral discs are characterised by a significant increase in the
number of senescent cells, which may be associated with the deterioration of this tissue due …

Metastatic disease is the major cause of cancer deaths, and recurrent tumors at distant
organs are a critical issue. However, how metastatic tumor cells become dormant and how …

The large doses of vitamins C and E and β-carotene used to reduce reactive oxygen species
(ROS) production and oxidative damages in cancerous tissue have produced disappointing …