Introduction Although many clinical studies have reported on the prevalence of dental pain,
far fewer studies have focused on the mechanisms of dental pain. This is an important gap …

Abstract Introduction Dental pulp fibroblasts (DPFs) are the most abundant cell type in the
dental pulp. They play pivotal roles; however, they are often mistaken to be involved only in …

As one of the most densely innervated tissues, the dental pulp contains abundant nerve
fibres, including sensory, sympathetic and parasympathetic nerve fibres. Studies in animal …

Neuropathic pain conditions including neuropathic orofacial pain (NOP) are difficult to treat.
Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain …

Objectives Billions of individuals worldwide suffer from periodontal disease, an inflammatory
disease that results in hard‐tissue and soft‐tissue destruction. A viable therapeutic option to …

Background: Transient Receptor Potential (TRP) channels are non-selective Ca2+
permeable channels with a wide and dynamic involvement in the perception of …

The tooth has an unusual sensory system that converts external stimuli predominantly into
pain, yet its sensory afferents in teeth demonstrate cytochemical properties of non …

Objective Acute pulpitis is one of the common causes of tooth pain. TACAN (Tmem120a) is a
newly identified ion channel that senses mechanical pain. In this experiment, we studied the …

The tooth–periodontium complex and its nerves have active reciprocal regulation during
development and homeostasis. These effects are predominantly mediated by a range of …

Orofacial pain represents one of the most common health problems that negatively affects
the activities of daily living. However, the mechanisms underlying these conditions are still …