Disorders of spermatogenesis: perspectives for novel genetic diagnostics after 20 years of unchanged routine

F Tüttelmann, C Ruckert, A Röpke - Medizinische Genetik, 2018 - degruyter.com
Infertility is a common condition estimated to affect 10–15% of couples. The clinical causes
are attributed in equal parts to the male and female partners. Diagnosing male infertility …

Genetics of male infertility

C Krausz, V Rosta, RS Swerdloff, C Wang - Emery and rimoin's principles …, 2022 - Elsevier
Approximately 7% of men suffer from fertility problems, the etiology of which are ascribable
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …

Male infertility: pathogenesis and clinical diagnosis

C Krausz - Best practice & research Clinical endocrinology & …, 2011 - Elsevier
Infertility affects about 7% of all men. The etiology of impaired sperm production and function
can be related to factors acting at pre-testicular, post-testicular or directly at the testicular …

Genetics of male infertility: from research to clinic

C Krausz, AR Escamilla, C Chianese - Reproduction, 2015 - rep.bioscientifica.com
Male infertility is a multifactorial complex disease with highly heterogeneous phenotypic
representation and in at least 15% of cases, this condition is related to known genetic …

[HTML][HTML] The genetic causes of male factor infertility: a review

KLO O'brien, AC Varghese, A Agarwal - Fertility and sterility, 2010 - Elsevier
OBJECTIVE: To illustrate the necessity for an enhanced understanding of the genetic basis
of male factor infertility, to present a comprehensive synopsis of these genetic elements, and …

A comprehensive review of genetics and genetic testing in azoospermia

AJ Hamada, SC Esteves, A Agarwal - Clinics, 2013 - SciELO Brasil
Azoospermia due to obstructive and non-obstructive mechanisms is a common
manifestation of male infertility accounting for 10-15% of such cases. Known genetic factors …

TEX11 is mutated in infertile men with azoospermia and regulates genome‐wide recombination rates in mouse

F Yang, S Silber, NA Leu, RD Oates… - EMBO molecular …, 2015 - embopress.org
Genome‐wide recombination is essential for genome stability, evolution, and speciation.
Mouse Tex11, an X‐linked meiosis‐specific gene, promotes meiotic recombination and …

[HTML][HTML] Genetic causes of spermatogenic failure

A Massart, W Lissens, H Tournaye… - Asian journal of …, 2012 - ncbi.nlm.nih.gov
Abstract Approximately 10%–15% of couples are infertile, and a male factor is involved in
almost half of these cases. This observation is due in part to defects in spermatogenesis …

Clinical genetic testing for male factor infertility: current applications and future directions

J Hotaling, DT Carrell - Andrology, 2014 - Wiley Online Library
Spermatogenesis involves the aggregated action of up to 2300 genes, any of which, could,
potentially, provide targets for diagnostic tests of male factor infertility. Contrary to the …

Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent

KI Aston, C Krausz, I Laface, E Ruiz-Castane… - Human …, 2010 - academic.oup.com
BACKGROUND In spite of tremendous efforts by a number of groups, the search for single
nucleotide polymorphisms (SNPs) strongly associated with male factor infertility by means of …