Propofol is an intravenous short‐acting anesthetic widely used to induce and maintain
general anesthesia and to provide procedural sedation. The potential for propofol …

Liver is a central nexus integrating metabolic and immunologic homeostasis in the human
body, and the direct or indirect target of most molecular therapeutics. A wide spectrum of …

Diabetic neuropathic pain (DNP) is a common, complex, and severe complication of
diabetes. It can lead to increased mortality, lower-limb amputations, and distressing …

General anesthetics can cause neurological damage and long-term behavioral/cognitive
impairment during fetal and early postnatal life. However, the adverse influence on embryo …

Interindividual variability in response to drugs used in anesthesia has long been considered
the rule, not the exception. It is important to mention that in anesthesiology, the variability in …

A variety of techniques have been developed to monitor the depth of anaesthesia. Propofol's
pharmacokinetics and response vary greatly, which might be explained by genetic …

Abstract Propofol (2, 6-diisopropylphenol) is one of the safest and most commonly used
anaesthetic agents for intravenous general anaesthesia. However, in clinical practice, a …

Women recover faster from propofol anaesthesia and have been described to have a higher
incidence of awareness during surgery, compared to men–an effect that may be inherent in …

Significant individual susceptibility to intravenous anesthetic propofol exists. The etiology of
individual variability in the response to propofol may be influenced by genetic …

Paediatric sedation has expanded in volume and demand over the past decade. In parallel
with the increasing demand for and delivery of sedation by multi-specialty providers …