The wide range of patient responses to surgical pain, opioids, and anesthetic agents has
puzzled anesthesiologists for many years. Much of the variation has been attributed to …

Background Propofol is a widely used intravenous hypnotic. Dosing is mostly based on
weight with great interindividual variation in consumption. Suggested factors affecting …

Background Based on the randomised Euro-EWING99-R1 trial, vincristine, adriamycin,
cyclophosphamide (VAC) may be able to replace vincristine, adriamycin, ifosfamide (VAI) in …

Obesity represents one of the most important public health issues according to the World
Health Organization. Additionally, in a recent National Health and Nutrition Survey of 2011 …

Responses to sedatives, analgesics and muscle relaxants vary among patients under
general anesthesia, which could be ascribed to the disparities of clinical characteristics and …

In this issue of the British Journal of Anaesthesia, Joksimovic and colleagues report
significant sex differences in sensitivity to the behavioural and neurophysiological effects of …

Objective The primary aim of this article is to test the hypothesis that nonparametric
pharmacometric modeling will accurately identify CYP2B6 genotype subgroups based on …

Purpose Propofol is one of the most widely used fast-acting intravenously administered
anesthetics. However, although large inter-individual differences in dose requirements and …

Background Attention‐deficit hyperactivity disorder (ADHD) is the most common
neurobehavioral disorder of childhood, affecting 5–8% of children. It has been observed that …

Abstract UDP-glucuronosyltransferase 1A9 (UGT1A9) is a major phase II enzyme
responsible for elimination of drugs and endogenous molecules. Clinical data have shown …