Application of ketoreductase in asymmetric synthesis of pharmaceuticals and bioactive molecules: an update (2018–2020)
Z Li, H Yang, J Liu, Z Huang, F Chen - The Chemical Record, 2021 - Wiley Online Library
With the rapid development of genomic DNA sequencing, recombinant DNA expression,
and protein engineering, biocatalysis has been increasingly and widely adopted in the …
and protein engineering, biocatalysis has been increasingly and widely adopted in the …
Statins in the treatment of dyslipidemia in the presence of elevated liver aminotransferase levels: a therapeutic dilemma
The beneficial role of statins in primary and secondary prevention of coronary heart disease
has resulted in their frequent use in clinical practice. However, safety concerns, especially …
has resulted in their frequent use in clinical practice. However, safety concerns, especially …
Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic …
D Lu, C Qu, A Goussev, H Jiang, C Lu… - Journal of …, 2007 - liebertpub.com
Traumatic brain injury (TBI) remains a major public health problem globally. Presently, there
is no way to restore cognitive deficits caused by TBI. In this study, we seek to evaluate the …
is no way to restore cognitive deficits caused by TBI. In this study, we seek to evaluate the …
[HTML][HTML] Grain sorghum lipid extract reduces cholesterol absorption and plasma non-HDL cholesterol concentration in hamsters
TP Carr, CL Weller, VL Schlegel, SL Cuppett… - The journal of …, 2005 - Elsevier
Grain sorghum is a rich source of phytochemicals that could potentially benefit human
health. In this study, male hamsters were fed AIN-93M diets supplemented with a hexane …
health. In this study, male hamsters were fed AIN-93M diets supplemented with a hexane …
The role of cholesterol metabolism in Alzheimer's disease
JH Sun, JT Yu, L Tan - Molecular neurobiology, 2015 - Springer
Alzheimer's disease (AD) is the most common type of dementias and becoming a worldwide
problem. As the time goes by, more and more researches show that AD is related to …
problem. As the time goes by, more and more researches show that AD is related to …
Biocatalysis for the asymmetric synthesis of Active Pharmaceutical Ingredients (APIs): This time is for real
G de Gonzalo, AR Alcántara… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Biocatalysis has emerged as a powerful and useful strategy for the synthesis of
active pharmaceutical ingredients (APIs). The outstanding developments in molecular …
active pharmaceutical ingredients (APIs). The outstanding developments in molecular …
Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans
AA Farooqui, WY Ong, LA Horrocks, P Chen… - Brain research …, 2007 - Elsevier
Neural membranes are composed of glycerophospholipids, sphingolipids, cholesterol and
proteins. The distribution of these lipids within the neural membrane is not random but …
proteins. The distribution of these lipids within the neural membrane is not random but …
Alzheimer's disease, cholesterol, and statins: the junctions of important metabolic pathways
T Silva, J Teixeira, F Remiao… - Angewandte Chemie …, 2013 - Wiley Online Library
Recent years have seen a significant increase in published data supporting the positive
effects of statins on neurodegenerative diseases, in particular on Alzheimer's disease …
effects of statins on neurodegenerative diseases, in particular on Alzheimer's disease …
[HTML][HTML] Biocatalyzed synthesis of statins: A sustainable strategy for the preparation of valuable drugs
Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are the
largest selling class of drugs prescribed for the pharmacological treatment of …
largest selling class of drugs prescribed for the pharmacological treatment of …
Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression
H Liu, SL Liang, S Kumar, CM Weyman, W Liu… - Cancer chemotherapy …, 2009 - Springer
Purpose Ovarian cancer is the leading cause of death among all gynecological
malignancies in Western countries. Although therapy for ovarian cancer has been greatly …
malignancies in Western countries. Although therapy for ovarian cancer has been greatly …