Thirteen women who were scheduled for hysterectomy volunteered for the study. Nine
women had a levonorgestrel‐releasing intrauterine contraceptive device inserted between …

This manuscript serves as a review of Mirena®, the levonorgestrel intrauterine system (LNG
IUS) as a very successful drug delivery system. The LNG IUS has a very high contraceptive …

Non-degradable polymers have an important function in medicine. Solid dosage forms for
longer term implantation require to be constructed from materials that will not degrade or …

Contraceptive vaginal rings delivering various progestins alone or in combination with
estrogen have been previously studied, showing adequate steroid vaginal absorption and …

A contraceptive vaginal ring containing levonorgestrel and estradiol was designed in which
the drug is located in a 0.15-mm layer beneath a 0.25-mm overcoat at the ring's surface …

Implantable drug delivery systems provide extended release of a drug for the desired
duration, usually over timespans of months and years. A broad range of materials are …

Biomedical engineering approaches used to develop controlled-release delivery systems for
hormones are here reviewed regarding system design and therapeutic applications. The …

Two types of intravaginal rings (IVR) containing 50–128 mg of levonorgestrel (LNOG) and
28–60 mg of estradiol were inserted in 18 apparently normal subjects belonging to the low …

This Thesis describes three pieces of work, all of which were commissioned by the World
Health Organization Special Programme in Human Reproduction which are concerned with …

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