Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …

Introduction Estrogens used in women's healthcare have been associated with increased
risks of venous thromboembolism (VTE) and breast cancer. Estetrol (E4), an estrogen …

Estetrol (E4) is a natural estrogenic steroid that is normally produced by human fetal liver.
Recent research has demonstrated that it is a potent, orally bioavailable, natural selective …

Objectives To evaluate the effect on endocrine and metabolic parameters of a new
combined oral contraceptive (COC) containing estetrol (E4) and drospirenone (DRSP) …

Objective To assess the effect on hemostasis parameters of a new combined oral
contraceptive (COC). Study design In this randomized, single centre, open-label, exploratory …

Objective To assess efficacy, cycle control, and safety of an oral contraceptive containing
estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg. Study design Women aged 16 to 50 …

Objectives To assess the contraceptive efficacy, bleeding pattern and safety of a combined
oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg. Design …

Estetrol/drospirenone is a combined oral contraceptive (COC) with a plant-synthesised
foetal oestrogen (estetrol) and a well-established progestin (drospirenone). In preclinical …

Estrogens have pleiotropic effects on many reproductive and non-reproductive tissues and
organs including the mammary gland, uterus, ovaries, vagina, and endothelium. Estrogen …

Objectives: To evaluate tolerability and safety of estetrol (E4) 15 mg/drospirenone (DRSP) 3
mg oral contraceptive using pooled data from two, multicenter, phase 3 trials. Study design …