Estrogen receptor alpha (ERα) and beta (ERβ) are members of the nuclear receptor
superfamily, playing widespread functions in reproductive and non-reproductive tissues …

Combined oral contraceptives (COCs) induce several changes in the levels of coagulation
factors. The levels of procoagulant factors are often increased, while levels of anticoagulant …

STUDY QUESTION Does an estradiol-based combined oral contraceptive (COC) have a
milder effect on the serum proteome than an ethinylestradiol (EE)-based COC or dienogest …

Estetrol (E4), a natural estrogen synthesized by the human fetal liver, is currently evaluated
in phase III clinical studies as a new menopause hormone therapy. Indeed, E4 significantly …

Background The cardiovascular protective effects of estrogens in premenopausal women
depend mainly on estrogen receptor α (ERα). ERα activates nuclear gene transcription …

Hematopoietic stem and progenitor cells (HSPC) are crucial in the maintenance of lifelong
production of all blood cells. These stem cells are highly regulated to maintain homeostasis …

Women now spend more than one-third of their lives in the postmenopausal years, and the
decline of endogenous estrogen production during menopause is accompanied by a series …

Estetrol (E4) is a natural estrogen with promising therapeutic applications in humans. The
European Medicines Agency and the Food and Drug Administration have approved the use …

Introduction: Menopausal symptoms have a substantial effect on the quality of life of many
women; hence, investigations for the amelioration of menopausal symptoms continue to be …

Purpose: Postmenopausal women with estrogen receptor-positive breast cancers often
respond initially to tamoxifen or aromatase inhibitor therapy. Resistance to these treatments …