Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …

After the discovery of Helicobacter pylori (H. pylori), and the evidence of its relationship with
gastric diseases, antibiotic-based therapies were developed, which efficacy was however …

Short tandem repeat (STR) variation has been proposed as a major explanatory factor in the
heritability of complex traits in humans and model organisms. However, we still struggle to …

Inflammation, especially chronic inflammation, is closely linked to tumor development. As
essential chronic inflammatory cytokines, the interleukin family plays a key role in …

Helicobacter pylori colonizes the gastric mucosa of more than 50% of the human population,
causing chronic inflammation, which however is largely asymptomatic. Nevertheless, H …

There is compelling evidence that senescent cells, through the senescence-associated
secretory phenotype (SASP), can promote malignant transformation and invasion …

Helicobacter pylori (H. pylori) infection is the most common chronic bacterial infection in the
world and the etiological agent for most gastric cancer (GC). Interleukin-1β (IL-1β) is a potent …

Background: The interleukin-1-receptor antagonist IL1RA (encoded by the IL1RN gene) is a
potent competitive antagonist to interleukin-1 (IL1) and thereby is mainly involved in the …

Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide and
one of the deadliest cancers in Asia. But at present, effective targets for HCC clinical therapy …

Within the past decade, inflammatory and lipid mediators, such as IL-1β, FABP4 and RAGE,
have emerged as important contributors to metabolic dysfunction. As growing experimental …