[HTML][HTML] Challenges of applying multicellular tumor spheroids in preclinical phase
SJ Han, S Kwon, KS Kim - Cancer Cell International, 2021 - Springer
Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …
becoming an essential tool in cancer research as it expresses an intermediate complexity …
[HTML][HTML] Three-dimensional in vitro culture models in oncology research
Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
[HTML][HTML] Three-dimensional in vitro cell culture models in drug discovery and drug repositioning
SA Langhans - Frontiers in pharmacology, 2018 - frontiersin.org
Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …
from target identification to lead discovery and optimization, preclinical validation and …
[HTML][HTML] Halfway between 2D and animal models: are 3D cultures the ideal tool to study cancer-microenvironment interactions?
An area that has come to be of tremendous interest in tumor research in the last decade is
the role of the microenvironment in the biology of neoplastic diseases. The tumor …
the role of the microenvironment in the biology of neoplastic diseases. The tumor …
3D tumor spheroids: an overview on the tools and techniques used for their analysis
EC Costa, AF Moreira, D de Melo-Diogo… - Biotechnology …, 2016 - Elsevier
In comparison with 2D cell culture models, 3D spheroids are able to accurately mimic some
features of solid tumors, such as their spatial architecture, physiological responses …
features of solid tumors, such as their spatial architecture, physiological responses …
[HTML][HTML] Three‑dimensional cell culture: A powerful tool in tumor research and drug discovery
D Lv, Z Hu, L Lu, H Lu, X Xu - Oncology letters, 2017 - spandidos-publications.com
In previous years, three‑dimensional (3D) cell culture technology has become a focus of
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …
[HTML][HTML] In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform
In vitro tumor models have provided important tools for cancer research and serve as low-
cost screening platforms for drug therapies; however, cancer recurrence remains largely …
cost screening platforms for drug therapies; however, cancer recurrence remains largely …
Advances in multicellular spheroids formation
Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure,
dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a …
dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a …
Biomimetic liposomal nanoplatinum for targeted cancer chemophototherapy
Photodynamic therapy (PDT) of cancer is limited by tumor hypoxia. Platinum nanoparticles
(nano‐Pt) as a catalase‐like nanoenzyme can enhance PDT through catalytic oxygen …
(nano‐Pt) as a catalase‐like nanoenzyme can enhance PDT through catalytic oxygen …
[PDF][PDF] Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation
An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by
bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of …
bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of …