There is growing interest in the implementation of microsampling approaches for the
quantitation of circulating concentrations of analytes in biological samples derived from …

The need for investigating alcohol abuse by means of objective tools is worldwide accepted.
Among the currently available biomarkers of chronic alcohol abuse, carbohydrate-deficient …

BACKGROUND: As rates of neonatal opioid withdrawal are increasing, the need for
research to evaluate new treatments is growing. Large heterogeneity exists in health …

Dried blood spot (DBS) microsampling is extensively employed in newborn screening (NBS)
and neonatal studies. However, the impact of variable neonatal hematocrit (Ht) values on …

Introduction: Drug dosing in infants frequently depends on body weight as a crude indicator
for maturation. Fentanyl (metabolized by Cytochrome P450 3A4) and morphine …

Introduction: For safe and effective neonatal antibiotic therapy, knowledge of the
pharmacokinetic parameters of antibacterial agents in neonates is a prerequisite. Fast …

Milk is often used as a dispersion medium for medicines administration in young children but
its taste-masking ability is unknown. A human taste panel was conducted to assess the …

Neonatal sepsis still remains a significant cause of morbidity and mortality, prolonged
hospitalization, and increased medical costs. Early-and late-onset sepsis often presents with …

A pediatric formulation workshop entitled “Pediatric Formulations: Challenges of Today and
Strategies for Tomorrow” was held to advance pediatric drug product development efforts in …

The bioavailability of a drug is usually assessed in healthy subjects. However, it is
reasonable to expect that significant alterations in bioavailability may occur in actual patients …