Natural coumarins: exploring the pharmacological complexity and underlying molecular mechanisms

J Sharifi-Rad, N Cruz-Martins… - Oxidative Medicine …, 2021 - Wiley Online Library
Coumarins belong to the benzopyrone family commonly found in many medicinal plants.
Natural coumarins demonstrated a wide spectrum of pharmacological activities, including …

[HTML][HTML] Coumarin: A natural, privileged and versatile scaffold for bioactive compounds

A Stefanachi, F Leonetti, L Pisani, M Catto, A Carotti - Molecules, 2018 - mdpi.com
Many naturally occurring substances, traditionally used in popular medicines around the
world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal …

Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

A Thakur, R Singla, V Jaitak - European journal of medicinal chemistry, 2015 - Elsevier
Coumarins are fused benzene and pyrone ring systems which prompt biological
investigation to assess their potential therapeutic significance. It possesses immeasurable …

Review on natural coumarin lead compounds for their pharmacological activity

KN Venugopala, V Rashmi… - BioMed research …, 2013 - Wiley Online Library
Coumarin (2H‐1‐benzopyran‐2‐one) is a plant‐derived natural product known for its
pharmacological properties such as anti‐inflammatory, anticoagulant, antibacterial …

Targeting Nrf2/Keap1 signaling pathway by bioactive natural agents: Possible therapeutic strategy to combat liver disease

R Jayasuriya, U Dhamodharan, D Ali, K Ganesan, B Xu… - Phytomedicine, 2021 - Elsevier
Background Nuclear factor erythroid 2-related factor (Nrf2), a stress-activated transcription
factor, has been documented to induce a defense mechanism against oxidative stress …

[HTML][HTML] Coumarins as fungal metabolites with potential medicinal properties

OM Tsivileva, OV Koftin, NV Evseeva - Antibiotics, 2022 - mdpi.com
Coumarins are a structurally varied set of 2 H-chromen-2-one compounds categorized also
as members of the benzopyrone group of secondary metabolites. Coumarin derivatives …

Multi-spectroscopic and molecular modelling studies on the interaction of esculetin with calf thymus DNA

T Sarwar, MA Husain, SU Rehman, HM Ishqi… - Molecular …, 2015 - pubs.rsc.org
Understanding the interaction of small molecules with DNA has become an active research
area at the interface between chemistry, molecular biology and medicine. Plant derived …

Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency

A Lichota, L Gwozdzinski, K Gwozdzinski - European Journal of Medicinal …, 2019 - Elsevier
The term varicose vein refers to the twisted and swollen vein visible under the skin surface
which occurs most commonly in the leg. Epidemiological studies report a varying …

[HTML][HTML] Targeting mammalian 5-lipoxygenase by dietary phenolics as an anti-inflammatory mechanism: A systematic review

JA Giménez-Bastida, A Gonzalez-Sarrias… - International Journal of …, 2021 - mdpi.com
5-Lipoxygenase (5-LOX) plays a key role in inflammation through the biosynthesis of
leukotrienes and other lipid mediators. Current evidence suggests that dietary (poly) …

茵陈的化学成分和药理作用研究进展

曹锦花 - 沈阳药科大学学报, 2013 - cqvip.com
目的对茵陈药材在化学成分和药理作用方面的研究进行综述. 方法通过系统的文献调研,
以近年来的50 余篇中外文文献为依据对茵陈的化学成分和药理作用进行归纳总结 …