Despite substantial progress in the development of antiretroviral regimens that durably
suppress Human Immunodeficiency Virus (HIV) infection, new agents that maintain high …

Antiretroviral therapy has changed human immunodeficiency virus (HIV) infection from a
near-certainly fatal illness to one that can be managed chronically. More patients are taking …

ContextTenofovir disoproxil fumarate (DF) is a once-daily nucleotide analogue reverse
transcriptase inhibitor. ObjectiveTo evaluate the efficacy and safety of tenofovir DF …

Tenofovir (TDF) is an effective and widely used treatment for both human immunodeficiency
virus (HIV) and hepatitis B virus infection. Although studies suggest that TDF has a low …

Tenofovir is an acyclic nucleotide analogue reverse‐transcriptase inhibitor structurally
similar to the nephrotoxic drugs adefovir and cidofovir. Tenofovir is widely used to treat HIV …

Twenty-five years ago, nucleoside analog 3′-azidothymidine (AZT) was shown to efficiently
block the replication of HIV in cell culture. Subsequent studies demonstrated that AZT acts …

Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse
transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years …

Drug-induced kidney injury is a major side effect in clinical practice, frequently leading to
acute renal failure (ARF). It accounts for more than 2% to 15% of cases of ARF in patients …

Mitochondrial dysfunction is increasingly implicated in the etiology of drug-induced toxicities.
Members of diverse drug classes undermine mitochondrial function, and among the most …

2010 revision Page 1 ANTIRETROVIRAL ThERApy fOR hIV INfEcTION IN INfANTs ANd
chILdREN: TOwARds uNIVERsAL AccEss Recommendations for a public health approach 2010 …