Programmed death ligand 1 signals in cancer cells
The paradigm of surface-expressed programmed death ligand 1 (PDL1) signalling to
immune cell programmed death 1 (PD1) to inhibit antitumour immunity has helped to …
immune cell programmed death 1 (PD1) to inhibit antitumour immunity has helped to …
The role of hypoxia‐inducible factor 1 in tumor immune evasion
L You, W Wu, X Wang, L Fang, V Adam… - Medicinal research …, 2021 - Wiley Online Library
Abstract Hypoxia‐inducible factor 1 (HIF‐1) plays an indispensable role in the hypoxic tumor
microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of tumor progression …
microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of tumor progression …
Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours
Checkpoint blockade therapy targeting the programmed-death ligand 1 (PD-L1) and its
receptor programmed cell death 1 promotes T-cell-mediated immunosurveillance against …
receptor programmed cell death 1 promotes T-cell-mediated immunosurveillance against …
[HTML][HTML] Advances in understanding N-glycosylation structure, function, and regulation in health and disease
S Esmail, MF Manolson - European journal of cell biology, 2021 - Elsevier
N-linked glycosylation is a post-translational modification crucial for membrane protein
folding, stability and other cellular functions. Alteration of membrane protein N-glycans is …
folding, stability and other cellular functions. Alteration of membrane protein N-glycans is …
The multi-faceted ecto-enzyme CD38: roles in immunomodulation, cancer, aging, and metabolic diseases
CD38 (Cluster of Differentiation 38) is a multifunctional ecto-enzyme that metabolizes NAD+
and mediates nicotinamide dinucleotide (NAD+) and extracellular nucleotide homeostasis …
and mediates nicotinamide dinucleotide (NAD+) and extracellular nucleotide homeostasis …
WNT signaling in tumors: the way to evade drugs and immunity
E Martin-Orozco, A Sanchez-Fernandez… - Frontiers in …, 2019 - frontiersin.org
WNT/β-catenin signaling is involved in many physiological processes. Its implication in
embryonic development, cell migration, and polarization has been shown. Nevertheless …
embryonic development, cell migration, and polarization has been shown. Nevertheless …
TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype
DA Sallman, AF McLemore, AL Aldrich… - Blood, The Journal …, 2020 - ashpublications.org
Somatic gene mutations are key determinants of outcome in patients with myelodysplastic
syndromes (MDS) and secondary AML (sAML). In particular, patients with TP53 mutations …
syndromes (MDS) and secondary AML (sAML). In particular, patients with TP53 mutations …
Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell …
W Fang, T Zhou, H Shi, M Yao, D Zhang, H Qian… - Journal of Experimental …, 2021 - Springer
Background Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in
multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the …
multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the …
HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity
Expression of programmed cell death 1 (PD-1) ligand 1 (PD-L1) protects tumor cells from T
cell–mediated immune surveillance, and immune checkpoint blockade (ICB) therapies …
cell–mediated immune surveillance, and immune checkpoint blockade (ICB) therapies …
The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis
N-linked glycosylation is one of the most abundant posttranslational modifications of
membrane-bound proteins in eukaryotes and affects a number of biological activities …
membrane-bound proteins in eukaryotes and affects a number of biological activities …