The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …

Abstract TOR (T arget O f R apamycin) is a highly conserved protein kinase that is important
in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive …

De novo somatic mutations in focal areas are well documented in diseases such as
neoplasia but are rarely reported in malformation of the developing brain …

Anaplastic thyroid carcinoma (ATC) is a frequently lethal malignancy that is often
unresponsive to available therapeutic strategies. The tumorigenesis of ATC and its …

The phosphatidylinositol‐3‐kinase (PI3K)/AKT/mTOR signaling pathway plays an essential
role in regulation of normal cell growth, metabolism, and survival. Somatic activating …

Target of rapamycin (TOR) was first identified in yeast as a target molecule of rapamycin, an
anti-fugal and immunosuppressant macrolide compound. In mammals, its orthologue is …

The recent surge in high-throughput sequencing of cancer genomes has supported an
expanding molecular classification of cancer. These studies have identified putative …

The mammalian target of rapamycin (mTOR) plays a key role in regulation of cellular
metabolism, growth, and proliferation. The frequent hyperactivation of mTOR signaling …

Understanding the genetic mechanisms of sensitivity to targeted anticancer therapies may
improve patient selection, response to therapy, and rational treatment designs. One …

The mTOR pathway was discovered in the late 1970s after the compound and natural
inhibitor of mTOR, rapamycin was isolated from the bacterium Streptomyces hygroscopicus …