[HTML][HTML] The extracellular matrix of hematopoietic stem cell niches
C Lee-Thedieck, P Schertl, G Klein - Advanced Drug Delivery Reviews, 2022 - Elsevier
Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …
Hematopoietic stem cell niche in health and disease
Regulation of stem cells in adult tissues is a key determinant of how well an organism can
respond to the stresses of physiological challenge and disease. This is particularly true of …
respond to the stresses of physiological challenge and disease. This is particularly true of …
Distinct bone marrow blood vessels differentially regulate haematopoiesis
Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both
leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance …
leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance …
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors
Breast cancer patients often develop locoregional or distant recurrence years after
mastectomy. Understanding the mechanism of metastatic recurrence after dormancy is …
mastectomy. Understanding the mechanism of metastatic recurrence after dormancy is …
Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells
F Bertolini, S Paul, P Mancuso, S Monestiroli, A Gobbi… - Cancer research, 2003 - AACR
There is growing evidence that vasculogenesis (progenitor cell-derived generation of new
blood vessels) is required for the growth of some neoplastic diseases. Here we show that …
blood vessels) is required for the growth of some neoplastic diseases. Here we show that …
Requirement for CD44 in homing and engraftment of BCR-ABL–expressing leukemic stem cells
DS Krause, K Lazarides, UH von Andrian… - Nature medicine, 2006 - nature.com
In individuals with chronic myeloid leukemia (CML) treated by autologous hematopoietic
stem cell (HSC) transplantation, malignant progenitors in the graft contribute to leukemic …
stem cell (HSC) transplantation, malignant progenitors in the graft contribute to leukemic …
Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2
Mice lacking the transcriptional repressor oncoprotein Gfi1 are unexpectedly neutropenic,.
We therefore screened GFI1 as a candidate for association with neutropenia in affected …
We therefore screened GFI1 as a candidate for association with neutropenia in affected …
Deletion of α4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing
LM Scott, GV Priestley… - Molecular and cellular …, 2003 - Taylor & Francis
We have explored the functional implications of inducible α4 integrin deletion during adult
hematopoiesis by generating a conditional-knockout mouse model, and we show that α4 …
hematopoiesis by generating a conditional-knockout mouse model, and we show that α4 …
Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells
E Chavakis, A Aicher, C Heeschen, K Sasaki… - The Journal of …, 2005 - rupress.org
The mechanisms of homing of endothelial progenitor cells (EPCs) to sites of ischemia are
unclear. Here, we demonstrate that ex vivo–expanded EPCs as well as murine …
unclear. Here, we demonstrate that ex vivo–expanded EPCs as well as murine …
Niche-to-niche migration of bone-marrow-derived cells
During ontogenesis, haematopoietic stem cells (HSCs) relocate between extra-embryonic
and embryonic compartments. Similarly, site-specific homing of HSCs is ongoing during …
and embryonic compartments. Similarly, site-specific homing of HSCs is ongoing during …