Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Ketogenesis and ketolysis are central metabolic processes activated during the response to
fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome …

Glutamate-mediated excitotoxicity, neuroinflammation, and oxidative stress are common
underlying events in neurodegeneration. This pathogenic “triad” characterizes the …

PFHxS (Perfluorohexane sulfonic acid) is one of the short-chain perfluoroalkyl substances
(PFASs) which are widely used in many industrial and consumer applications. However …

Background Neuroinflammatory processes are considered a double-edged sword, having
both protective and detrimental effects in the brain. Microglia, the brain's resident innate …

Retinoid X receptors (RXRs) control a wide variety of functions by virtue of their dimerization
with other nuclear hormone receptors (NRs), contributing thereby to activities of different …

Introduction. Parkinson's disease (PD) is the second most common neurodegenerative
disease after Alzheimer's disease (AD). With the ageing of population, the frequency of PD is …

Docosahexaenoic acid (DHA, 22: 6n-3) is an omega-3 polyunsaturated fatty acid (PUFA)
essential for neural development, learning, and vision. Although DHA can be provided to …

Alzheimer disease (AD), the most common cause of dementia, is a progressive disorder
involving cognitive impairment, loss of learning and memory, and neurodegeneration …

Long-chain omega-3 fatty acids esterified in lysophosphatidylcholine (LPC-omega-3) are
the most bioavailable omega-3 fatty acid form and are considered important for brain health …