Drug-induced liver injury in children: clinical observations, animal models, and regulatory status
Q Shi, X Yang, JJ Greenhaw… - International …, 2017 - journals.sagepub.com
Drug-induced liver injury in children (cDILI) accounts for about 1% of all reported adverse
drug reactions throughout all age groups, less than 10% of all clinical DILI cases, and …
drug reactions throughout all age groups, less than 10% of all clinical DILI cases, and …
Three promising antimycobacterial medicinal plants reviewed as potential sources of drug hit candidates against multidrug-resistant tuberculosis
N Tuyiringire, S Deyno, A Weisheit, CU Tolo… - Tuberculosis, 2020 - Elsevier
Regimens of current drugs for tuberculosis are lengthy and are associated with many
adverse effects. Currently, the emergence of different resistant strains has been observed …
adverse effects. Currently, the emergence of different resistant strains has been observed …
[HTML][HTML] Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage
GA Gutiérrez-Rebolledo, AG Siordia-Reyes… - Asian Pacific journal of …, 2016 - Elsevier
Objective To estimate to what extent the mixture of ursolic acid and oleanolic acid, in
addition to the antitubercular standard regime, affects the hepatotoxicity profile. Methods …
addition to the antitubercular standard regime, affects the hepatotoxicity profile. Methods …
The high incidence of severe adverse events due to pyrazinamide in elderly patients with tuberculosis
Background Pyrazinamide (PZA) is a common drug that causes serious adverse events
(SAEs). The aim of this study was to determine the incidence of and risk factors for SAEs due …
(SAEs). The aim of this study was to determine the incidence of and risk factors for SAEs due …
[HTML][HTML] First line anti-tuberculosis induced hepatotoxicity: incidence and risk factors
O El Bouazzi, S Hammi, JE Bourkadi… - The Pan African …, 2016 - ncbi.nlm.nih.gov
In our days, tuberculosis, whet ever its localization, became a curable disease. The
cornerstone is a 6 month course of isoniazid, rifampicine and pyrazinamide. All of the three …
cornerstone is a 6 month course of isoniazid, rifampicine and pyrazinamide. All of the three …
New one-pot synthesis of anti-tuberculosis compounds inspired on isoniazid
DG Ghiano, A Recio-Balsells, A Bortolotti… - European journal of …, 2020 - Elsevier
A library of thirty N-substituted tosyl N'-acryl-hydrazones was prepared with p-
toluenesulfonyl hydrazide, methyl propiolate and different aldehydes in a one-pot synthesis …
toluenesulfonyl hydrazide, methyl propiolate and different aldehydes in a one-pot synthesis …
Altered expressions of circulating microRNAs 122 and 192 during antitubercular drug induced liver injury indicating their role as potential biomarkers
S Bakshi, M Kaur, N Saini, AA Mir… - Human & …, 2021 - journals.sagepub.com
Drug induced liver toxicity is a serious health complication leading to high mortality rates
and post marketing withdrawal of drugs. Although considered to be the gold standard …
and post marketing withdrawal of drugs. Although considered to be the gold standard …
Risk factors of isoniazid-induced hepatotoxicity in Tunisian tuberculosis patients
N Ben Fredj, R Gam, E Kerkni, A Chaabane… - The …, 2017 - nature.com
Previous studies have shown controversial results on whether acetylator status causes
isoniazid-induced hepatotoxicity (IIH). Moreover, the contribution of CYP2E1, a hepatic …
isoniazid-induced hepatotoxicity (IIH). Moreover, the contribution of CYP2E1, a hepatic …
[HTML][HTML] High rate of adverse drug reactions with a novel tuberculosis re-treatment regimen combining triple doses of both isoniazid and rifampicin
MB Souleymane, S Kadri, A Piubello… - International Journal of …, 2023 - Elsevier
Objectives High-dose rifampicin (R) and isoniazid (H) are known to be safe but were not yet
combined in a single regimen. The primary objective of the TRIple-DOse RE-treatment …
combined in a single regimen. The primary objective of the TRIple-DOse RE-treatment …
Quercetin protected against isoniazide‐induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway
Y Zhang, W Zhang, L Tao, J Zhai, H Gao… - … of biochemical and …, 2019 - Wiley Online Library
Isoniazid (INH) is one of the most commonly used antituberculosis drugs, but its clinical
applications have been limited by severe hepatic toxicity. Quercetin (Que), a natural …
applications have been limited by severe hepatic toxicity. Quercetin (Que), a natural …