Drug-induced liver injury in children (cDILI) accounts for about 1% of all reported adverse
drug reactions throughout all age groups, less than 10% of all clinical DILI cases, and …

Regimens of current drugs for tuberculosis are lengthy and are associated with many
adverse effects. Currently, the emergence of different resistant strains has been observed …

Objective To estimate to what extent the mixture of ursolic acid and oleanolic acid, in
addition to the antitubercular standard regime, affects the hepatotoxicity profile. Methods …

Background Pyrazinamide (PZA) is a common drug that causes serious adverse events
(SAEs). The aim of this study was to determine the incidence of and risk factors for SAEs due …

In our days, tuberculosis, whet ever its localization, became a curable disease. The
cornerstone is a 6 month course of isoniazid, rifampicine and pyrazinamide. All of the three …

A library of thirty N-substituted tosyl N'-acryl-hydrazones was prepared with p-
toluenesulfonyl hydrazide, methyl propiolate and different aldehydes in a one-pot synthesis …

Drug induced liver toxicity is a serious health complication leading to high mortality rates
and post marketing withdrawal of drugs. Although considered to be the gold standard …

Previous studies have shown controversial results on whether acetylator status causes
isoniazid-induced hepatotoxicity (IIH). Moreover, the contribution of CYP2E1, a hepatic …

Objectives High-dose rifampicin (R) and isoniazid (H) are known to be safe but were not yet
combined in a single regimen. The primary objective of the TRIple-DOse RE-treatment …

Isoniazid (INH) is one of the most commonly used antituberculosis drugs, but its clinical
applications have been limited by severe hepatic toxicity. Quercetin (Que), a natural …