Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases

CR Harrell, N Jovicic, V Djonov, N Arsenijevic… - Cells, 2019 - mdpi.com
There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression
was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC …

Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - Stem cell research & …, 2022 - Springer
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

Immunomodulatory mechanisms and therapeutic potential of mesenchymal stem cells

G Yang, X Fan, Y Liu, P Jie, M Mazhar, Y Liu… - Stem Cell Reviews and …, 2023 - Springer
Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell
therapy, owing to their multipotent nature and ability to display potent and varied functions in …

Reproducible large-scale isolation of exosomes from adipose tissue-derived mesenchymal stem/stromal cells and their application in acute kidney injury

JH Lee, DH Ha, H Go, J Youn, H Kim, RC Jin… - International Journal of …, 2020 - mdpi.com
Acute kidney injury (AKI) is a fatal medical episode caused by sudden kidney damage or
failure, leading to the death of patients within a few hours or days. Previous studies …

[HTML][HTML] Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatmen

K Jayaramayya, I Mahalaxmi, MD Subramaniam… - BMB …, 2020 - ncbi.nlm.nih.gov
The world has witnessed unimaginable damage from the coronavirus disease-19 (COVID-
19) pandemic. Because the pandemic is growing rapidly, it is important to consider diverse …

Long-term effects of severe burns on the kidneys: research advances and potential therapeutic approaches

G Yang, L Tan, H Yao, Z Xiong, J Wu… - Journal of Inflammation …, 2023 - Taylor & Francis
Burns are a seriously underestimated form of trauma that not only damage the skin system
but also cause various complications, such as acute kidney injury (AKI). Recent clinical …

Exosomes derived from adipose mesenchymal stem cells restore functional endometrium in a rat model of intrauterine adhesions

S Zhao, W Qi, J Zheng, Y Tian, X Qi, D Kong… - Reproductive …, 2020 - Springer
Intrauterine adhesion (IUA) caused by endometrial injury is one of the important causes of
infertility in women of reproductive age and requires advanced treatment strategies …

Potential targeted therapy and diagnosis based on novel insight into growth factors, receptors, and downstream effectors in acute kidney injury and acute kidney injury …

LI Gao, X Zhong, J Jin, J Li, X Meng - Signal transduction and targeted …, 2020 - nature.com
Acute kidney injury (AKI) is defined as a rapid decline in renal function and is characterized
by excessive renal inflammation and programmed death of resident cells. AKI shows high …

Extracellular vesicles as mediators of cellular crosstalk between immune system and kidney graft

M Quaglia, S Dellepiane, G Guglielmetti… - Frontiers in …, 2020 - frontiersin.org
Extracellular vesicles (EVs) are known immune-modulators exerting a critical role in kidney
transplantation (KT). EV bioactive cargo includes graft antigens, costimulatory/inhibitory …

Stem cell therapies in kidney diseases: progress and challenges

C Rota, M Morigi, B Imberti - International journal of molecular sciences, 2019 - mdpi.com
The prevalence of renal diseases is emerging as a public health problem. Despite major
progress in supportive therapy, mortality rates among patients remain high. In an attempt to …