An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …

Migraine and major depression are debilitating disorders with high lifetime prevalence rates.
Interestingly these disorders are highly comorbid and show significant heritability …

Migraine is a leading cause of disability among the adult population and is a significant
burden on the economies of the world. Studies into the underlying causes of migraine have …

There is significant evidence to support the notion that glial cells can modulate the strength
of synaptic connections between nerve cells, and it has further been suggested that …

Background Serum CGRP has been found to increase during migraine attack. However,
whether CGRP can identify MA with PFO subtypes in MA remains unknown. This study …

Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches,
including migraines; however, the underlying mechanisms remain unknown. Therefore, we …

Migraine and major depressive disorders (MDD) or treatment resistant depression (TRD)
represent a significant global burden and are often comorbid, further complicating diagnosis …

Science is the art of systematic and reproducible measurements, ultimately leading to
knowledge supported by a holistic logic. Besides serendipity, there are 6 ways in general to …

This study analyzes the differences in potential biomarkers of migraine models constructed
by two commonly used modeling methods through metabolomics research. Migraine models …

Whilst a bidirectional relationship between sleep and migraine has long been postulated,
this remains mainly speculative, and the underlying neural mechanisms remain to be …