Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal
proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic …

Heart failure (HF) is a complication of multiple cardiac diseases and is characterized by
impaired contractile and electric function. Patients with HF are not only limited by reduced …

Human stem cell-derived cardiomyocytes (hSC-CMs) hold great promise as in vitro models
to study the electrophysiological effects of novel drug candidates on human ventricular …

Ischemic heart disease is a significant public health problem with high mortality and
morbidity. Extensive scientific investigations from basic sciences to clinics revealed …

Atrial fibrillation (AF) is frequently associated with β-adrenergic stimulation, especially in
patients with structural heart diseases. The objective of this study was to determine the …

Although late sodium current (I Na-late) has long been known to contribute to plateau
formation of mammalian cardiac action potentials, lately it was considered as possible target …

Rhythms of electrical activity in all regions of the heart can be influenced by a variety of
intracellular membrane bound organelles. This is true both for normal pacemaker activity …

Cardiac arrhythmias cause significant morbidity and mortality and pose a major public
health problem. They arise from disruptions in the normally orderly propagation of cardiac …

Background Recent evidence revealed that glucose fluctuation might be more likely to
cause arrhythmia than persistent hyperglycemia, whereas its mechanisms were elusive. We …

Background Long QT syndrome 3 (LQT3) is caused by SCN5A mutations. Late sodium
current (late I Na) inhibitors are current-specific to treat patients with LQT3, but the …