Cutaneous T cell lymphoma

R Dummer, MH Vermeer, JJ Scarisbrick… - Nature Reviews …, 2021 - nature.com
Primary cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphomas
that present in the skin with no evidence of extracutaneous disease at the time of diagnosis …

T-cell large granular lymphocyte leukemia and related disorders

MG Rose, N Berliner - The oncologist, 2004 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to: Discuss
the clinical manifestations of large granular lymphocyte leukemia and related disorders …

TCR repertoire as a novel indicator for immune monitoring and prognosis assessment of patients with cervical cancer

JH Cui, KR Lin, SH Yuan, YB Jin, XP Chen… - Frontiers in …, 2018 - frontiersin.org
There is increasing evidence that deep sequencing-based T cell repertoire can sever as a
biomarker of immune response in cancer patients; however, the characteristics of T cell …

Age‐related loss of naive T cells and dysregulation of T‐cell/B‐cell interactions in human lymph nodes

L Lazuardi, B Jenewein, AM Wolf, G Pfister… - …, 2005 - Wiley Online Library
In this study we analysed the effects of age on T and B lymphocytes in human lymph nodes
by comparing lymphocyte subsets in paraffin sections from lymph node tissue taken from …

Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies Report of the BIOMED-2 Concerted Action BHM4 CT98-3936

M Brüggemann, H White, P Gaulard, R Garcia-Sanz… - Leukemia, 2007 - nature.com
Polymerase chain reaction (PCR) assessment of clonal T-cell receptor (TCR) and
immunoglobulin (Ig) gene rearrangements is an important diagnostic tool in mature T-cell …

Sequence analysis of complex amplicons

M Faham, M Moorhead, T Willis - US Patent 9,523,129, 2016 - Google Patents
US Appl. No. 14/404,435, filed Nov. 26, 2014, Faham et al. Bertness, et al. T-cell receptor
gene rearrangements as clinical (60) Provisional application No. 61/112,693, filed on Nov …

Methods of monitoring conditions by sequence analysis

M Faham, T Willis - US Patent 10,246,752, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
42153463&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Random array sequencing of low-complexity libraries

J Zheng, T Willis, M Faham - US Patent 10,385,475, 2019 - Google Patents
The invention is directed to a method of sequencing low-complexity amplicons randomly
arrayed at high density on a surface. Methods of the invention include preparing amplicons …

The predictive value of PNH clones, 6p CN-LOH, and clonal TCR gene rearrangement for aplastic anemia diagnosis

YB Shah, SF Priore, Y Li, CN Tang, P Nicholas… - Blood …, 2021 - ashpublications.org
Acquired aplastic anemia (AA) is a life-threatening bone marrow aplasia caused by the
autoimmune destruction of hematopoietic stem and progenitor cells. There are no existing …

Monitoring health and disease status using clonotype profiles

M Faham, T Willis - US Patent 9,512,487, 2016 - Google Patents
2022-09-15 Assigned to ORBIMED ROYALTY & CREDIT OPPORTUNITIES IV, LP
reassignment ORBIMED ROYALTY & CREDIT OPPORTUNITIES IV, LP SECURITY …