Navigating Available Treatment Options for Carbapenem-Resistant Acinetobacter baumannii-calcoaceticus Complex Infections

RK Shields, DL Paterson… - Clinical Infectious …, 2023 - academic.oup.com
Carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRAB) is one of
the top-priority pathogens for new antibiotic development. Unlike other antibiotic-resistant …

Mechanisms and clinical relevance of bacterial heteroresistance

DI Andersson, H Nicoloff, K Hjort - Nature Reviews Microbiology, 2019 - nature.com
Antibiotic heteroresistance is a phenotype in which a bacterial isolate contains
subpopulations of cells that show a substantial reduction in antibiotic susceptibility …

Global Epidemiology and Mechanisms of Resistance of Acinetobacter baumannii-calcoaceticus Complex

M Castanheira, RE Mendes… - Clinical Infectious …, 2023 - academic.oup.com
Acinetobacter baumannii-calcoaceticus complex is the most commonly identified species in
the genus Acinetobacter and it accounts for a large percentage of nosocomial infections …

World Health Organization report: current crisis of antibiotic resistance

A Talebi Bezmin Abadi, AA Rizvanov, T Haertlé… - BioNanoScience, 2019 - Springer
Antibiotic resistance is the most challenging clinical and public health problem. Despite of
living in the era of novel technologies in biomedical research, many of untreatable infectious …

Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

CR Lee, JH Lee, M Park, KS Park, IK Bae… - Frontiers in cellular …, 2017 - frontiersin.org
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification

H Nicoloff, K Hjort, BR Levin, DI Andersson - Nature microbiology, 2019 - nature.com
When choosing antibiotics to treat bacterial infections, it is assumed that the susceptibility of
the target bacteria to an antibiotic is reflected by laboratory estimates of the minimum …

Convergence of Biofilm Formation and Antibiotic Resistance in Acinetobacter baumannii Infection

S Roy, G Chowdhury, AK Mukhopadhyay… - Frontiers in …, 2022 - frontiersin.org
Acinetobacter baumannii (A. baumannii) is a leading cause of nosocomial infections as this
pathogen has certain attributes that facilitate the subversion of natural defenses of the …

Insight into Acinetobacter baumannii: pathogenesis, global resistance, mechanisms of resistance, treatment options, and alternative modalities

M Asif, IA Alvi, SU Rehman - Infection and drug resistance, 2018 - Taylor & Francis
Acinetobacter baumannii, once considered a low-category pathogen, has emerged as an
obstinate infectious agent. The scientific community is paying more attention to this …

New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections

B Isler, Y Doi, RA Bonomo… - Antimicrobial agents and …, 2019 - Am Soc Microbiol
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a perilous nosocomial pathogen
causing substantial morbidity and mortality. Current treatment options for CRAB are limited …

Molecular mechanisms of antibiotic resistance

JMA Blair, MA Webber, AJ Baylay, DO Ogbolu… - Nature reviews …, 2015 - nature.com
Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly
common and are causing a global health crisis. Antibiotic resistance is encoded by several …