Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Abstract Purpose of Review Our goal is to examine the processes—both central and
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …

The brush of a feather and a pinprick are perceived as distinct sensations because they are
detected by discrete cutaneous sensory neurons. Inflammation or nerve injury can disrupt …

Tissue injury and inflammation markedly alter touch perception, making normally innocuous
sensations become intensely painful. Although this sensory distortion, known as tactile …

Nociception and pain is a large field of both neuroscience and medical research. Over time,
various tests and models were developed in rodents to provide tools for fundamental and …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …

Peripheral nerve injuries induce a pronounced immune reaction within the spinal cord,
largely governed by microglia activation in both the dorsal and ventral horns. The …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain, including neuropathic pain. While this comorbidity is clinically …

Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are
incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a …