This review proposes that lipopolysaccharide (LPS, found in the wall of all Gram-negative
bacteria) could play a role in causing sporadic Alzheimer's disease (AD). This is based in …

Alzheimer's disease [AD] is the most common cause of dementia in North America. Despite
30+ years of intense investigation, the field lacks consensus regarding the etiology and …

Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous
system. With recognition of its roles in synaptic plasticity (long-term potentiation, LTP; long …

Alzheimer's disease (AD) is the most common cause of dementia and one of the most
important causes of morbidity and mortality among the aging population. AD diagnosis is …

Although substantial evidence indicates that the progression of pathological changes of the
neuronal cytoskeleton is crucial in determining the severity of dementia in Alzheimer's …

The brain's high energy requirements and limited storage capacity make persistent cerebral
blood flow (CBF) critical for its proper functioning as well as for the prevention of damage …

Rosacea is a common chronic inflammatory disease affecting the facial skin whose etiology
and pathophysiology are the subject of much investigation. Risk factors include genetic and …

Oxidative stress has been implicated in a number of neurodegenerative diseases spanning
various fields of research. Reactive oxygen species can be beneficial or harmful, depending …

Background Neurodegenerative diseases are among the most common diseases in older
adults worldwide. Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the …

As fundamental research advances, it is becoming increasingly clear that a clinically
expressed disease implies a mixture of intertwining molecular disturbances. Oxidative stress …