Understanding and controlling fluorinated diacyl peroxides and fluoroalkyl radicals in alkene fluoroalkylations
S Kawamura, M Sodeoka - The Chemical Record, 2023 - Wiley Online Library
The demand for practical methods for the synthesis of novel fluoroalkyl molecules is
increasing owing to their diverse applications. Our group has achieved efficient …
increasing owing to their diverse applications. Our group has achieved efficient …
Phosphine Catalysis of the Fluorination of Unactivated Tertiary Alkyl Chlorides under Mild and Convenient Conditions
ZY Wang, DJ Freas, GC Fu - Journal of the American Chemical …, 2023 - ACS Publications
Due to the significance of organofluorine compounds in disciplines ranging from medicine to
agriculture to materials science, the invention of new methods for the creation of carbon …
agriculture to materials science, the invention of new methods for the creation of carbon …
Copper-catalysed radical reactions of alkenes, alkynes and cyclopropanes with N–F reagents
JM Muñoz-Molina, TR Belderrain… - Organic & Biomolecular …, 2020 - pubs.rsc.org
The mild generation of nitrogen-centred radicals from N–F reagents has become a
convenient synthetic tool. This methodology provides access to the aminative …
convenient synthetic tool. This methodology provides access to the aminative …
Difluorination of heterobenzylic C–H bonds with N-fluoro-N-(fluorosulfonyl) carbamate (NFC)
N-Heterocycles constitute an important structural moiety of small molecules in
pharmaceuticals and agrochemicals. Fluorination of heterobenzylic C–H bonds in these …
pharmaceuticals and agrochemicals. Fluorination of heterobenzylic C–H bonds in these …
Selective C–F bond etherification of trifluoromethylalkenes with phenols
Q Tian, B Pei, C Wang, C Zhang… - The Journal of Organic …, 2022 - ACS Publications
Selective functionalization of a single sp3 C–F bond of the CF3 group represents an
appealing way to generate the pharmaceutically privileged difluoromethylene moiety …
appealing way to generate the pharmaceutically privileged difluoromethylene moiety …
Cu‐Catalyzed C− H Perfluoroalkylation/Cyclization of Unactivated Alkenes: Synthesis of Perfluoroalkylated Tricyclimidazoles
Z Guo, X Chen, Y Xue, J Li, D Zou… - Advanced Synthesis & …, 2022 - Wiley Online Library
A copper‐catalyzed cascade difunctionalization of unactivated olefins with readily available
Rf‐I reagents to construct Csp3− CF2/C− C bonds has been reported. This strategy provides …
Rf‐I reagents to construct Csp3− CF2/C− C bonds has been reported. This strategy provides …
The Acidities of Nucleophilic Monofluoromethylation Reagents: An Anomalous α‐Fluorine Effect
H Zheng, Z Li, J Jing, XS Xue… - Angewandte Chemie, 2021 - Wiley Online Library
Fluorine incorporation into organic molecules is expected to lower the pKa of neighboring
functionality via its strong electron‐withdrawing effect, and this strategy has been widely …
functionality via its strong electron‐withdrawing effect, and this strategy has been widely …
Synthesis of Chiral 1,1,1-Trifluoro-α,α-disubstituted 2,4-Diketones via Palladium-Catalyzed Asymmetric Allylation
G Chen, J Mo, D Jiang, Y Peng - Organic Letters, 2023 - ACS Publications
Trifluoromethyl ketones are important enzyme inhibitors and versatile synthons for the
preparation of trifluoromethylated heterocycles and complex molecules. An efficient …
preparation of trifluoromethylated heterocycles and complex molecules. An efficient …
The Smallest Monofluorodiazoethane Reagent and Its [3+ 2] Cycloaddition Reactions
X Tang, MY He, R Guo, HN Liu, J Nie, I Marek… - CCS …, 2024 - chinesechemsoc.org
Given the widespread applications of fluorinated substances in pharmaceuticals, biology,
and materials, the development of fluorine-containing building blocks remains an important …
and materials, the development of fluorine-containing building blocks remains an important …
Application of Oxidative Ring Opening/Ring Closing by Reductive Amination Protocol for the Stereocontrolled Synthesis of Functionalized Azaheterocycles
The current Account gives an insight into the synthesis of some N-heterocyclic β-amino acid
derivatives and various functionalized saturated azaheterocycles accessed from substituted …
derivatives and various functionalized saturated azaheterocycles accessed from substituted …