Proteasomes are the central proteolytic machines that are critical for breaking down most of
the damaged and abnormal proteins in human cells. Although universally applicable drugs …

The tight regulation of proteostasis is essential for physiological cellular function.
Mammalian cells possess a network of mechanisms that ensure proteome integrity under …

The transcription factor nuclear factor erythroid 2 like 1 (NFE2L1 or NRF1) regulates
constitutive and inducible expression of proteasome subunits and assembly chaperones …

Background: Proteasome 26S subunit, ATPase gene (PSMC) family members play a critical
role in regulating protein degradation and are essential for tumor development. However …

The 26S proteasome irreversibly hydrolyzes polyubiquitylated substrates to maintain protein
homeostasis; it also regulates immune responses by generating antigenic peptides. An …

Dry immersion (DI) is one of the most widely used terrestrial microgravity models. Dry
immersion accurately and quickly reproduces most of the physiological effects of the early …

Background Embryonal tumors with multilayered rosettes (ETMR) are rare malignant
embryonal brain tumors. The prognosis of ETMR is poor and novel therapeutic approaches …

Purpose The objective of the present investigation was to establish a molecular association
of different proteases as cancer targets with the indinavir and how the physicochemical …

Background Immunoproteasome, a part of ubiquitin–proteasome system, is involved in
immune response as well as protein degradation. However, the relationship between …

Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant
neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to …