The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …

Polycystic liver diseases (PLDs) are inherited genetic disorders characterized by
progressive development of intrahepatic, fluid-filled biliary cysts (more than ten), which …

Bile duct epithelial cells, also known as cholangiocytes, regulate the composition of bile and
its flow. Acquired, congenital and genetic dysfunctions in these cells give rise to a set of …

Polycystic liver disease (PLD) is a group of genetic disorders characterized by progressive
development of cholangiocyte-derived fluid-filled hepatic cysts. PLD is the most common …

Research on transient receptor potential vanilloid-4 (TRPV4) can provide a promising
potential therapeutic target in the development of novel medicines for lung disorders. TRPV4 …

Polycystic liver disease (PLD) is a rare hereditary disease that independently exists in
isolated PLD, or as an accompanying symptom of autosomal dominant polycystic kidney …

Apoptosis in the cystic epithelium is observed in most rodent models of polycystic kidney
disease (PKD) and in human autosomal dominant PKD (ADPKD). Apoptosis inhibition …

Polycystic liver disease (PLD) is a clinical condition characterized by the presence of more
than 10 cysts in the liver. It is a rare disease Of genetic etiology that presents as an isolated …

Reduced ciliary expression is reported in several tumors, including cholangiocarcinoma
(CCA). We previously showed primary cilia have tumor suppressor characteristics, and …

Abstract Background & Aims Polycystic liver diseases (PLDs) are genetic disorders
characterized by progressive development of multiple biliary cysts. Recently, novel PLD …