[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

Hyperoside: A review on its sources, biological activities, and molecular mechanisms

Q Wang, HC Wei, SJ Zhou, Y Li, TT Zheng… - Phytotherapy …, 2022 - Wiley Online Library
Hyperoside is a natural flavonol glycoside in various plants, such as Crataegus pinnatifida
Bge, Forsythia suspensa, and Cuscuta chinensis Lam. Medical research has found that …

[HTML][HTML] Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model

Z Pei, Y Qin, X Fu, F Yang, F Huo, X Liang, S Wang… - Redox biology, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by
excessive proliferation of fibroblasts and excessive accumulation of extracellular matrix …

[HTML][HTML] Hyperoside: a review of its structure, synthesis, pharmacology, pharmacokinetics and toxicity

S Xu, S Chen, W Xia, H Sui, X Fu - Molecules, 2022 - mdpi.com
Hyperoside is an active ingredient in plants, such as Hypericum monogynum in
Hypericaceae, Crataegus pinnatifida in Rosaceae and Polygonum aviculare in …

[HTML][HTML] CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis

J Wu, L Chen, C Qin, F Huo, X Liang, X Yang… - … and Targeted Therapy, 2022 - nature.com
COVID‐19 patients can develop clinical and histopathological features associated with
fibrosis, but the pathogenesis of fibrosis remains poorly understood. CD147 has been …

[HTML][HTML] PI3K signaling in mechanisms and treatments of pulmonary fibrosis following sepsis and acute lung injury

JP Margaria, L Moretta, JC Alves-Filho, E Hirsch - Biomedicines, 2022 - mdpi.com
Pulmonary fibrosis is a pathological fibrotic process affecting the lungs of five million people
worldwide. The incidence rate will increase even more in the next years due to the long …

[HTML][HTML] Therapeutic effects and molecular mechanisms of bioactive compounds against respiratory diseases: traditional Chinese medicine theory and high-frequency …

J Wang, Q Wu, L Ding, S Song, Y Li, L Shi… - Frontiers in …, 2021 - frontiersin.org
Respiratory diseases, especially the pandemic of respiratory infectious diseases and
refractory chronic lung diseases, remain a key clinical issue and research hot spot due to …

Hyperoside suppresses NLRP3 inflammasome in Parkinson's disease via pituitary adenylate cyclase-activating polypeptide

K Wang, C Lu, T Wang, C Qiao, L Lu, D Wu… - Neurochemistry …, 2022 - Elsevier
Abstract NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome-induced
neuroinflammation is the main pathogenic mechanism of dopaminergic (DA) neuron …

[HTML][HTML] Coal dust nanoparticles induced pulmonary fibrosis by promoting inflammation and epithelial-mesenchymal transition via the NF-κB/NLRP3 pathway driven …

Y Zhang, J Liang, N Cao, J Gao, L Song, X Tang - Cell death discovery, 2022 - nature.com
Pneumoconiosis is the most common and serious disease among coal miners. In earlier
work on this subject, we documented that coal dust (CD) nanoparticles (CD-NPs) induced …

[HTML][HTML] Exosomal microRNA-140-3p from human umbilical cord mesenchymal stem cells attenuates joint injury of rats with rheumatoid arthritis by silencing SGK1

Y Huang, L Chen, D Chen, P Fan, H Yu - Molecular Medicine, 2022 - Springer
Objective Over the years, microRNAs (miRNAs) have been involved in the pathogenesis of
rheumatoid arthritis (RA). We aim to investigate the role of human umbilical cord …