Numerous efforts to understand the functional roles of antibodies demonstrated that they can
protect against malaria. However, it is unclear which antibody responses are the best …

With increasing malaria control and goals of malaria elimination, many endemic areas are
transitioning from high-to-low-to-no malaria transmission. Reductions in transmission will …

Background An understanding of the mechanisms mediating protective immunity against
malaria in humans is currently lacking, but critically important to advance the development of …

Antigenic diversity has posed a critical barrier to vaccine development against the
pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To …

Natural killer (NK) cells are potent immune effectors that can be activated via antibody-
mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK …

The induction of cellular immunity, in conjunction with antibodies, may be essential for
vaccines to protect against blood-stage infection with the human malaria parasite …

Individuals in areas of Plasmodium falciparum endemicity develop immunity to malaria after
repeated exposure. Knowledge of the acquisition and nature of protective immune …

Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication
in naturally-acquired and vaccine-induced immunity; however, specific targets of these …

Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver
stages and the disease-causing blood stages of the human malaria parasite Plasmodium …

No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum,
which cause the symptoms and severe manifestations of malaria. We recently found that …