The anti-cancer agent CBP501 binds to calmodulin (CaM). Recent studies showed that
migration and metastasis are inhibited by several CaM antagonists. However, there is no …

Since their identification over 15 years ago, the IQGAP (IQ-motif-containing GTPase-
activating protein) family of proteins have been implicated in a wide range of cellular …

IQGAP1 is a scaffold protein whose function relates to signal transduction, cell adhesion,
local invasion, and distant metastasis of cancer cells. We examined the expression patterns …

Cell migration, a highly complex physiological phenomenon that requires the co-ordinated
and tightly regulated function of several proteins, is mediated by a number of signalling …

Calmodulin is a ubiquitous signalling protein that controls many biological processes due to
its capacity to interact and/or regulate a large number of cellular proteins and pathways …

IQGAP1 contains a number of protein recognition motifs through which it binds to targets.
Several in vitro studies have documented that IQGAP1 interacts directly with calmodulin …

IQGAP is a recently identified actin-binding protein, which is a putative target for the Cdc42
and Rac GTP-binding proteins. Cdc42 was localized to the Golgi (Erickson, JW, Zhang, C …

IQ motif‐containing GTPase‐activating proteins IQGAP1 and IQGAP2 are highly
homologous multidomain scaffolding proteins. Their major function consists of integration of …

IQGAP1, is a recently discovered scaffold protein proposed to regulate membrane
cytoskeleton events through protein–protein interactions with F‐actin, E‐cadherin, β …

AIM: To understand the interaction of human IQGAP1 and CDC42, especially the effects of
phosphorylation and a cancer-associated mutation. METHODS: Recombinant CDC42 and a …