[HTML][HTML] Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
BF Haynes, K Wiehe, P Borrow, KO Saunders… - Nature Reviews …, 2023 - nature.com
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive.
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
[HTML][HTML] The long road toward COVID-19 herd immunity: vaccine platform technologies and mass immunization strategies
LSF Frederiksen, Y Zhang, C Foged… - Frontiers in …, 2020 - frontiersin.org
There is an urgent need for effective countermeasures against the current emergence and
accelerating expansion of coronavirus disease 2019 (COVID-19), caused by severe acute …
accelerating expansion of coronavirus disease 2019 (COVID-19), caused by severe acute …
Vaccination induces HIV broadly neutralizing antibody precursors in humans
Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …
[HTML][HTML] Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
Memory B cells play a fundamental role in host defenses against viruses, but to date, their
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
[HTML][HTML] Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection
Pre-existing immunity to seasonal endemic coronaviruses could have profound
consequences for antibody responses to SARS-CoV-2, induced from natural infection or …
consequences for antibody responses to SARS-CoV-2, induced from natural infection or …
[HTML][HTML] Antibody affinity shapes the choice between memory and germinal center B cell fates
C Viant, GHJ Weymar, A Escolano, S Chen… - Cell, 2020 - cell.com
Immunological memory is required for protection against repeated infections and is the basis
of all effective vaccines. Antibodies produced by memory B cells play an essential role in …
of all effective vaccines. Antibodies produced by memory B cells play an essential role in …
[HTML][HTML] Recent progress in broadly neutralizing antibodies to HIV
D Sok, DR Burton - Nature immunology, 2018 - nature.com
In this Review, we highlight some recent developments in the discovery and application of
broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); ie …
broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); ie …
[HTML][HTML] Restricted clonality and limited germinal center reentry characterize memory B cell reactivation by boosting
L Mesin, A Schiepers, J Ersching, A Barbulescu… - Cell, 2020 - cell.com
Repeated exposure to pathogens or their antigens triggers anamnestic antibody responses
that are higher in magnitude and affinity than the primary response. These involve …
that are higher in magnitude and affinity than the primary response. These involve …
[HTML][HTML] CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
[HTML][HTML] Precursor frequency and affinity determine B cell competitive fitness in germinal centers, tested with germline-targeting HIV vaccine immunogens
How precursor frequencies and antigen affinities impact interclonal B cell competition is a
particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …
particularly relevant issue for candidate germline-targeting HIV vaccine designs because of …