Therapeutic effect of palmitoylethanolamide in cognitive decline: A systematic review and preliminary meta-analysis of preclinical and clinical evidence

M Colizzi, R Bortoletto, C Colli, E Bonomo… - Frontiers in …, 2022 - frontiersin.org
Cognitive decline is believed to be associated with neurodegenerative processes involving
excitotoxicity, oxidative damage, inflammation, and microvascular and blood-brain barrier …

Effect of ultra-micronized palmitoylethanolamide and luteolin on olfaction and memory in patients with long COVID: results of a longitudinal study

P De Luca, A Camaioni, P Marra, G Salzano… - Cells, 2022 - mdpi.com
In this study, we investigated whether treatment with palmitoylethanolamide and luteolin
(PEA-LUT) leads to improvement in the quantitative or qualitative measures of olfactory …

Synaptic effects of palmitoylethanolamide in neurodegenerative disorders

M Assogna, F Di Lorenzo, A Martorana, G Koch - Biomolecules, 2022 - mdpi.com
Increasing evidence strongly supports the key role of neuroinflammation in the
pathophysiology of neurodegenerative diseases, such as Alzheimer's disease …

What Is the Role of Palmitoylethanolamide Co-Ultramicronized with Luteolin on the Symptomatology Reported by Patients Suffering from Long COVID? A …

M Pirro, L Ferri, L Piccioni, AM Bellucci, F Bartolucci… - Nutrients, 2023 - mdpi.com
Long COVID is a recognized post-viral syndrome characterized by neurological, somatic
and neuropsychiatric symptoms that might last for long time after SARS-CoV-2 infection. An …

The beneficial effects of ultramicronized palmitoylethanolamide in the management of neuropathic pain and associated mood disorders induced by paclitaxel in mice

C Cristiano, C Avagliano, M Cuozzo, FM Liguori… - Biomolecules, 2022 - mdpi.com
Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication of
antineoplastic drugs, particularly paclitaxel (PTX). It can affect the quality of patients' lives …

The multiple sclerosis modulatory potential of natural multi-targeting antioxidants

P Theodosis-Nobelos, EA Rekka - Molecules, 2022 - mdpi.com
Multiple sclerosis (MS) is a complex neurodegenerative disease. Although its pathogenesis
is rather vague in some aspects, it is well known to be an inflammatory process …

Impact of TRPV1 on Pathogenesis and Therapy of Neurodegenerative Diseases

W Wang, T Sun - Molecules, 2023 - mdpi.com
Transient receptor potential vanilloid 1 (TRPV1) is a transmembrane and non-selective
cation channel protein, which can be activated by various physical and chemical stimuli …

Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of parkinsonism

F Palese, S Pontis, N Realini, A Torrens… - Pharmacological …, 2022 - Elsevier
The lysosomal cysteine hydrolase N-acylethanolamine acid amidase (NAAA) deactivates
palmitoylethanolamide (PEA), a lipid-derived PPAR-α agonist that is critically involved in the …

CSF N-acylethanolamine acid amidase level and Parkinson's disease risk: A mendelian randomization study

Y Zeng, R Guo, S Cao, C Liu, H Yang - Parkinsonism & Related Disorders, 2024 - Elsevier
Background Neuroinflammation is involved in the progression of Parkinson's disease (PD),
and N-acylethanolamine acid amidase (NAAA) is involved in regulating inflammation by …

PEALut in the Dietary Management of Patients with Acute Ischemic Stroke: A Prospective Randomized Controlled Clinical Trial

M Bonzanino, M Riolo, I Battaglini, M Perna… - Journal of Clinical …, 2024 - mdpi.com
Acute ischemic stroke (AIS), which represents 87% of all strokes, is caused by reduced
blood supply to the brain associated with a prolonged inflammatory process that …