Click chemistry-aided drug discovery: A retrospective and prospective outlook
R Zhao, J Zhu, X Jiang, R Bai - European Journal of Medicinal Chemistry, 2023 - Elsevier
Click chemistry has emerged as a valuable tool for rapid compound synthesis, presenting
notable advantages and convenience in the exploration of potential drug candidates. In …
notable advantages and convenience in the exploration of potential drug candidates. In …
[HTML][HTML] Indole-based compounds as potential drug candidates for SARS-CoV-2
AS Girgis, SS Panda, BM Kariuki, MS Bekheit… - Molecules, 2023 - mdpi.com
The COVID-19 pandemic has posed a significant threat to society in recent times,
endangering human health, life, and economic well-being. The disease quickly spreads due …
endangering human health, life, and economic well-being. The disease quickly spreads due …
[HTML][HTML] Molecular hybridization of alkaloids using 1, 2, 3-triazole-based click chemistry
Alkaloids found in multiple species, known as 'driver species', are more likely to be included
in early-stage drug development due to their high biodiversity compared to rare alkaloids …
in early-stage drug development due to their high biodiversity compared to rare alkaloids …
Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study
Complications of the worldwide use of non-steroidal anti-inflammatory drugs (NSAIDs)
sparked scientists to design novel harmless alternatives as an urgent need. So, a unique …
sparked scientists to design novel harmless alternatives as an urgent need. So, a unique …
[HTML][HTML] Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties
DR Aboshouk, MA Youssef, MS Bekheit, AR Hamed… - RSC …, 2024 - pubs.rsc.org
Cancer is one of the most significant health challenges worldwide. Various techniques, tools
and therapeutics/materials have been developed in the last few decades for the treatment of …
and therapeutics/materials have been developed in the last few decades for the treatment of …
[HTML][HTML] Indole Compounds in Oncology: Therapeutic Potential and Mechanistic Insights
Cancer remains a formidable global health challenge, with current treatment modalities such
as chemotherapy, radiotherapy, surgery, and targeted therapy often hindered by low efficacy …
as chemotherapy, radiotherapy, surgery, and targeted therapy often hindered by low efficacy …
Effect of felodipine on indomethacin-induced gastric ulcers in rats
N Akbaş, B Süleyman, R Mammadov… - Experimental …, 2023 - jstage.jst.go.jp
Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties.
Researchers have stated that oxidative stress and inflammation also play a role in the …
Researchers have stated that oxidative stress and inflammation also play a role in the …
Bionic synthesis of novel monoterpenoid indole alkaloid-like analogs with tyrosinase inhibition activity based on loganetin
H Qiu, L Deng, J Li, M Zhang, X Hao, C Yuan… - Journal of Molecular …, 2024 - Elsevier
A series of novel monoterpenoid indole alkaloid (MIA)-like analogs (1–24) were synthesized
by using a biomimetic synthetic strategy and combinatorial chemistry. The tyrosinase …
by using a biomimetic synthetic strategy and combinatorial chemistry. The tyrosinase …
Bioinformática en la evaluación de constituyentes del LECISAN con proteínas dianas del metabolismo oxidativo y procesos inflamatorios
L Cala-Calviño, SS Santiago… - Revista Cubana de …, 2023 - revinformatica.sld.cu
En la búsqueda de nuevos fármacos, el objetivo principal es encontrar moléculas que
puedan interferir alguna vía o señal metabólica responsable de una enfermedad. El objetivo …
puedan interferir alguna vía o señal metabólica responsable de una enfermedad. El objetivo …