Nearly all licensed vaccines have been developed to confer protection against infectious
diseases by stimulating the production of antibodies by B cells, but the nature of a successful …

Positron emission tomography (PET) and single-photon emission computed tomography
(SPECT) are molecular imaging strategies that typically use radioactively labeled ligands to …

Antibodies have become the modality of choice within the biopharma industry because they
possess several characteristics that are attractive to those developing therapeutic …

Heterobifunctional protein fusions are gaining interest as next-generation
biopharmaceuticals.[1–5] Combining proteins with disparate functions can enable multidrug …

In contrast to averaging methods of determining structure, such as X-ray diffraction, NMR,
and single-particle tomography, cryo-electron tomography allows three-dimensional …

The conformational flexibility of antibodies in solution directly affects their immune function.
Namely, the flexible hinge regions of immunoglobulin G (IgG) antibodies are essential in …

The advantages of chicken (Gallus gallus domesticus) antibodies as immunodiagnostic and
immunotherapeutic biomolecules has only been recently recognized. Even so, chicken …

The binding of Abs to microbial surfaces followed by complement activation constitutes an
important line of defense against infections. In this study, we have investigated the …

Engineered cell instructive microenvironments with the ability to stimulate specific cellular
responses are a topic of high interest in the fabrication and development of biomaterials for …

The synaptonemal complex (SC) is a meiosis-specific nuclear multiprotein complex that is
essential for proper synapsis, recombination and segregation of homologous chromosomes …