SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …

Perceiving environmental and internal information and reacting in adaptive ways are
essential attributes of living organisms. Two-component systems are relevant protein …

Two-component systems (TCSs) are a ubiquitous family of signal transduction pathways that
enable bacteria to sense and respond to physical, chemical, and biological stimuli outside …

DNA–protein interactions are central to fundamental cellular processes, yet widely
implemented technologies for measuring these interactions on a genome scale in bacteria …

Over the past decades, our understanding of microbial metabolism has increased
dramatically. Metabolomics, a family of techniques that are used to measure the quantities of …

Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few
treatment options being available. New therapeutics are urgently needed to relieve the …

In rod‐shaped bacteria, type IV pili (Tfp) promote twitching motility by assembling and
retracting at the cell pole. In Myxococcus xanthus, a bacterium that moves in highly …

Bacteria are single-celled organisms that carry a comparatively small set of genetic
information, typically consisting of a few thousand genes that can be selectively activated or …

While nucleic acid-targeting effectors are known to be central to biological conflicts and anti-
selfish element immunity, recent findings have revealed immune effectors that target their …

Several homologous domains are shared by eukaryotic immunity and programmed cell-
death systems and poorly understood bacterial proteins. Recent studies show these to be …