Redox sensing modulates the activity of the ComE response regulator of Streptococcus mutans

HPS Dhaked, L Cao, I Biswas - Journal of Bacteriology, 2021 - Am Soc Microbiol
Streptococcus mutans, a dental pathogen, encodes the ComDE two-component system
comprised of a histidine kinase (ComD) and a response regulator (ComE). This system is …

Regulation of constant cell elongation and Sfm pili synthesis in Escherichia coli via two active forms of FimZ orphan response regulator

A Ogawa, F Kojima, Y Miyake, M Yoshimura… - Genes to …, 2022 - Wiley Online Library
Escherichia coli (E. coli) has multiple copies of the chaperone‐usher (CU) pili operon in five
fimbria groups: CU pili, curli, type IV pili, type III secretion pili, and type IV secretion pili …

Research progress in biosensors based on bacterial two-component systems

Z Jingyu, J ZHANG, QI Qingsheng… - Synthetic Biology …, 2024 - synbioj.cip.com.cn
Two-component systems (TCSs) in bacteria, are capable of sensing and making responses
to physical, chemical, and biological stimuli within and outside the cells, and subsequently …

[HTML][HTML] The architectural dynamics of the bacterial flagellar motor switch

S Khan - Biomolecules, 2020 - mdpi.com
The rotary bacterial flagellar motor is remarkable in biochemistry for its highly synchronized
operation and amplification during switching of rotation sense. The motor is part of the …

Phospho‐dependent signaling during the general stress response by the atypical response regulator and ClpXP adaptor RssB

J Schwartz, J Son, C Brugger… - Protein …, 2021 - Wiley Online Library
In the model organism Escherichia coli and related species, the general stress response
relies on tight regulation of the intracellular levels of the promoter specificity subunit RpoS …

[PDF][PDF] Allosteric priming of E. coli CheY by the flagellar motor protein FliM

P Wheatley, S Gupta, A Pandini, Y Chen, CJ Petzold… - Biophysical journal, 2020 - cell.com
Abstract Phosphorylation of Escherichia coli CheY protein transduces chemoreceptor
stimulation to a highly cooperative flagellar motor response. CheY binds to the N-terminal …

Residue coevolution and mutational landscape for OmpR and NarL response regulator subfamilies

M Shibata, X Lin, JN Onuchic, K Yura, RR Cheng - Biophysical Journal, 2024 - cell.com
DNA-binding response regulators (DBRRs) are a broad class of proteins that operate in
tandem with their partner kinase proteins to form two-component signal transduction …

Purification, crystallization and crystallographic analysis of the PorX response regulator associated with the type IX secretion system

A Saran, N Weerasinghe, CJ Thibodeaux… - … Section F: Structural …, 2022 - scripts.iucr.org
Pathogenic bacteria utilize specialized macromolecular secretion systems to transport
virulence factors across membrane (s) and manipulate their infected host. To date, 11 …

[HTML][HTML] Regulation of gene expression by non-phosphorylated response regulators

C Gomez-Arrebola, C Solano, I Lasa - International Microbiology, 2021 - Springer
Two-component systems (TCSs) are a prominent sensory system in bacteria. A prototypical
TCS comprises a membrane-bound sensor histidine kinase (HK) responsible for sensing the …

Control of acetyl phosphate-dependent phosphorylation of the response regulator CiaR by acetate kinase in Streptococcus pneumoniae

S Kaiser, LM Hoppstädter, K Bilici, K Heieck… - …, 2020 - microbiologyresearch.org
The two-component regulatory system CiaRH of Streptococcus pneumoniae affects a large
variety of physiological processes including ß-lactam resistance, competence development …