Cancers make their own luck: theories of cancer origins
A Jassim, EP Rahrmann, BD Simons… - Nature reviews …, 2023 - nature.com
Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …
Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …
from fully understanding how proteins fold into their native conformation. The conventional …
Rare variant associations with plasma protein levels in the UK Biobank
Integrating human genomics and proteomics can help elucidate disease mechanisms,
identify clinical biomarkers and discover drug targets,,–. Because previous proteogenomic …
identify clinical biomarkers and discover drug targets,,–. Because previous proteogenomic …
Aging is associated with a systemic length-associated transcriptome imbalance
Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …
Translation and mRNA stability control
Q Wu, AA Bazzini - Annual review of biochemistry, 2023 - annualreviews.org
Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the
post-transcriptional process that profoundly impact protein production in a cell. While it is …
post-transcriptional process that profoundly impact protein production in a cell. While it is …
[HTML][HTML] Phylogenomic discovery of deleterious mutations facilitates hybrid potato breeding
Hybrid potato breeding will transform the crop from a clonally propagated tetraploid to a
seed-reproducing diploid. Historical accumulation of deleterious mutations in potato …
seed-reproducing diploid. Historical accumulation of deleterious mutations in potato …
Is the mutation rate lower in genomic regions of stronger selective constraints?
A study of the plant Arabidopsis thaliana detected lower mutation rates in genomic regions
where mutations are more likely to be deleterious, challenging the principle that …
where mutations are more likely to be deleterious, challenging the principle that …
Codon language embeddings provide strong signals for use in protein engineering
C Outeiral, CM Deane - Nature Machine Intelligence, 2024 - nature.com
Protein representations from deep language models have yielded state-of-the-art
performance across many tasks in computational protein engineering. In recent years …
performance across many tasks in computational protein engineering. In recent years …
A rugged yet easily navigable fitness landscape
Fitness landscape theory predicts that rugged landscapes with multiple peaks impair
Darwinian evolution, but experimental evidence is limited. In this study, we used genome …
Darwinian evolution, but experimental evidence is limited. In this study, we used genome …
Deep mutational scanning: A versatile tool in systematically mapping genotypes to phenotypes
H Wei, X Li - Frontiers in Genetics, 2023 - frontiersin.org
Unveiling how genetic variations lead to phenotypic variations is one of the key questions in
evolutionary biology, genetics, and biomedical research. Deep mutational scanning (DMS) …
evolutionary biology, genetics, and biomedical research. Deep mutational scanning (DMS) …