White adipose tissue (WAT) is a specialized tissue whose main function is lipid synthesis
and triglyceride storage. It is now considered as an active organ secreting a plethora of …

Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of
articular cartilage, inflammation, and changes in periarticular and subchondral bone of …

Objective To test the hypothesis that an altered gut microbiota (dysbiosis) plays a role in
obesity‐associated osteoarthritis (OA). Methods Stool and blood samples were collected …

Abstract Purpose of Review Metabolic syndrome (MetS), also called the 'deadly
quartet'comprising obesity, diabetes, dyslipidemia, and hypertension, has been ascertained …

The recent description of adipose tissues of various phenotypes within an osteoarthritic joint
allows us to evoke their direct involvement in the initiation and progression of the …

Since its discovery in 1994, leptin has been considered as an adipokine with pleiotropic
effects. In this review, we summarize the actual information about the impact of this hormone …

Adipokines are the principal mediators in adipose signaling. Nevertheless, besides their role
in energy storage, these molecules can be produced by other cells, such as immune cells or …

The adipose and bone tissues demonstrate considerable interconnected endocrine function.
In the present study, we determined the concentrations of fibroblast growth factor-23 (FGF …

Objective: Osteoarthritis (OA) is a common joint disorder characterized by degenerative
articular cartilage, subchondral bone remodeling, and inflammation. Increasing evidence …

Osteopontin (OPN) is a bone-derived phosphoglycoprotein related to physiological and
pathological mechanisms that nowadays has gained relevance due to its role in the immune …