Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …

Abstract Cancer-associated fibroblasts (CAFs), as a central component of the tumor
microenvironment in primary and metastatic tumors, profoundly influence the behavior of …

Simple Summary Colorectal cancer (CRC) is the third most common cancer worldwide.
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …

The peritoneum is an extensive serous organ with both epithelial and mesenchymal features
and a variety of functions. Diseases such as inflammatory peritonitis and peritoneal …

Peritoneal metastasis is a primary metastatic route for gastric cancers, and the mechanisms
underlying this process are still unclear. Peritoneal mesothelial cells (PMCs) undergo …

Tumor-associated tertiary lymphoid structures (TA-TLS) are associated with enhanced
patient survival and responsiveness to cancer therapies, but the mechanisms underlying …

Various types of tumors, particularly those originating from the ovary and gastrointestinal
tract, display a strong predilection for the peritoneal cavity as the site of metastasis. The …

Pancreatic tumors are known to harbor an abundant and highly desmoplastic stroma.
Among the various cell types that reside within tumor stroma, cancer-associated fibroblasts …

Significance: In the last years, metabolic reprogramming, fluctuations in bioenergetic fuels,
and modulation of oxidative stress became new key hallmarks of tumor development. In …

Simple Summary Cancer-associated fibroblasts (CAFs) are key players in the tumor
microenvironment. They are responsible for potentiating growth and metastasis through …