Persistent human papillomavirus infection

AN Della Fera, A Warburton, TL Coursey, S Khurana… - Viruses, 2021 - mdpi.com
Simple Summary The success of HPV as an infectious agent lies not within its ability to
cause disease, but rather in the adeptness of the virus to establish long-term persistent …

The not-so-good, the bad and the ugly: HPV E5, E6 and E7 oncoproteins in the orchestration of carcinogenesis

O Basukala, L Banks - Viruses, 2021 - mdpi.com
Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

Rapid clearance profile of plasma circulating tumor HPV type 16 DNA during chemoradiotherapy correlates with disease control in HPV-associated oropharyngeal …

BS Chera, S Kumar, BT Beaty, D Marron, S Jefferys… - Clinical Cancer …, 2019 - AACR
Purpose: To identify a profile of circulating tumor human papilloma virus (HPV) DNA
(ctHPVDNA) clearance kinetics that is associated with disease control after …

HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis

C Pan, N Issaeva, WG Yarbrough - Cancers of the head & neck, 2018 - Springer
Understanding of oropharyngeal squamous cell carcinoma has significantly progressed
over the last decades, and the concept that this disease can be subdivided into two distinct …

Extrachromosomal DNA in cancer

X Yan, P Mischel, H Chang - Nature Reviews Cancer, 2024 - nature.com
Extrachromosomal DNA (ecDNA) has recently been recognized as a major contributor to
cancer pathogenesis that is identified in most cancer types and is associated with poor …

Epigenetic regulation of the human papillomavirus life cycle

M Mac, CA Moody - Pathogens, 2020 - mdpi.com
Persistent infection with certain types of human papillomaviruses (HPVs), termed high risk,
presents a public health burden due to their association with multiple human cancers …

Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients

KH Bhatt, MA Neller, S Srihari, P Crooks… - Journal of Experimental …, 2020 - rupress.org
Cellular immunotherapeutics targeting the human papillomavirus (HPV)–16 E6 and E7
proteins have achieved limited success in HPV-positive oropharyngeal cancer (OPC). Here …

Control of viral latency by episome maintenance proteins

A De Leo, A Calderon, PM Lieberman - Trends in microbiology, 2020 - cell.com
The human DNA tumor viruses Epstein–Barr virus (EBV), Kaposi's sarcoma-associated
herpesvirus (KSHV), and human papillomavirus (HPV) share the common property of …

Novel antigenic targets of HPV therapeutic vaccines

DR Boilesen, KN Nielsen, PJ Holst - Vaccines, 2021 - mdpi.com
Human papillomavirus (HPV) infection is the cause of the majority of cervical cancers and
head and neck cancers worldwide. Although prophylactic vaccines and cervical cancer …

The host-microbe interplay in human papillomavirus-induced carcinogenesis

R Wakabayashi, Y Nakahama, V Nguyen, JL Espinoza - Microorganisms, 2019 - mdpi.com
Every year nearly half a million new cases of cervix cancer are diagnosed worldwide,
making this malignancy the fourth commonest cancer in women. In 2018, more than 270,000 …