Mucus is the first biological component inhaled drugs encounter on their journey towards
their pharmacological target in the upper airways. Yet, how mucus may influence drug …

There are few studies in humans dealing with the relationship between physico-chemical
properties of drugs and their systemic bioavailability after administration via oral inhalation …

Animal studies are an important component of drug product development and the regulatory
review process since modern practices have been in place, for almost a century. A variety of …

Background: Occupational exposure to xenobiotic aerosols may occur within different
settings, with a common example being the unintentional inhalation of pesticide aerosols …

Introduction: Drug particles inhaled via the respiratory system must first dissolve in the
respiratory tract lining fluid (RTLF) that lies on the surfaces of airways and alveoli, so that …

Mimicking the lung environment has always been a challenge with regards to dissolution
testing of inhaled drugs from dry powder inhalers (DPIs). The aim of this review is to critically …

Factors affecting deposition may be patient‐specific such as inspiratory profile, lung luminal
conditions, and airway geometry or drug product dependent such as inhalation device or …

Pseudomonas aeruginosa (PA) is the predominant pathogen in chronic lung infections of
cystic fibrosis (CF) patients. The most important mechanism of adaptation of PA to host …

Background Tuberculosis (TB), a global health problem caused by Mycobacterium
tuberculosis, mainly affects the lungs and spreads to other organs. Rifampicin is a potent …

Conjugation of recombinant human deoxyribonuclease I (rhDNase) to large (≥ 20 kDa)
polyethylene glycol (PEG) has been shown to prolong the lung residence time of the …