Recent advances in sequencing technologies and collaborative efforts have led to
substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS) …

Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that is
classically thought to impact the motor system. Over the past 20 years, research has started …

Objective To investigate the association between the use of common medications on
hypertension, hyperlipidemia, diabetes, and the risk of amyotrophic lateral sclerosis (ALS) …

Background/Aim: Type 2 diabetes (T2D), characterized by hyperinsulinemia, protects motor
neurons against amyotrophic lateral sclerosis (ALS). Type 1 diabetes and a total lack of …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by progressive loss of motor neurons. Emerging evidence suggests a …

Introduction Amyotrophic lateral sclerosis (ALS) is a devastating, uniformly lethal
degenerative disease of motor neurons, presenting with relentlessly progressive muscle …

Objective To assess the temporal relationship between premorbid lipid levels and long-term
amyotrophic lateral sclerosis (ALS) risk. Methods From Norwegian cardiovascular health …

Methods: Genes associated with ALS were identified using GWAS summary statistic
methodology including SuSiE SNP-based fine-mapping, and transcriptome-and proteome …

Background Type 2 diabetes (T2D), but not type 1, protected against ALS. In T2D serum
insulin is normal or elevated in the early stages. Type 1 diabetes, characterized by a total …