A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

Although acute exposure of the heart to angiotensin (Ang II) produces physiological cardiac
hypertrophy and chronic exposure results in pathological hypertrophy, the signal …

When faced with increased workload the heart undergoes remodelling, where it increases
its muscle mass in an attempt to preserve normal function. This is referred to as cardiac …

The prevalence of diabetes is growing at an alarming rate with increased disability,
morbidity, and often premature mortality because of the various complications of this …

The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …

Background: Pathological cardiac hypertrophy is one of the leading causes of heart failure
with highly complicated pathogeneses. The E3 ligase TRIM16 (tripartite motif–containing …

Metabolic cardiomyopathy is an emerging cause of heart failure in patients with obesity,
insulin resistance, and diabetes. It is characterized by impaired myocardial metabolic …

Nonalcoholic fatty liver disease (NAFLD), characterized by ectopic fat accumulation in
hepatocytes, is closely linked to insulin resistance and is the most frequent complication of …

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases regulate production of
reactive oxygen species (ROS) that cause oxidative damage to cellular components but also …

Under physiological conditions, reactive oxygen species (ROS) function as signaling
molecules that control cell function. However in pathological conditions, increased …