Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
affecting patients with cancer and patients with osteoporosis who have been treated with …

Early imaging signs of the use of antiresorptive medication and MRONJ: a systematic review

C Moreno-Rabié, H Gaêta-Araujo… - Clinical oral …, 2020 - Springer
Objective The main aim is to identify, by means of different imaging modalities, the early
bone changes in patients “at risk” and in stage 0 MRONJ. Materials and methods A search of …

Medication-related osteonecrosis of the jaw around dental implants: implant surgery-triggered or implant presence-triggered osteonecrosis?

I Giovannacci, M Meleti, M Manfredi… - Journal of …, 2016 - journals.lww.com
Methods: Fifteen patients with peri-implant bone osteonecrosis were selected out of a group
of 250 patients (6%). Patients were divided into 2 groups according to the temporal …

Osteonecrosis of the jaws (ONJ) in mice after extraction of teeth with periradicular disease

A Soundia, D Hadaya, N Esfandi, RS de Molon… - Bone, 2016 - Elsevier
Osteonecrosis of the jaws (ONJ) is a complication of antiresorptive medications, such as
denosumab or bisphosphonates, prescribed to patients with bone malignancy or …

The role of platelet‐rich fibrin (PRF) in the prevention of medication‐related osteonecrosis of the jaw (MRONJ)

M Miranda, F Gianfreda, C Raffone… - BioMed Research …, 2021 - Wiley Online Library
Dentoalveolar surgery is probably the major risk factor for MRONJ and for other
complications following a tooth extraction, especially in patients affected by systemic …

Rodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes

H Hadad, HR Matheus, SI Pai, FA Souza… - Archives of Oral …, 2023 - Elsevier
Objective To assess the outcomes of several rodent animal models for studying tooth
extraction-related medication-related osteonecrosis of the jaw (MRONJ). Design After a …

Pathogenesis of medication-related osteonecrosis of the jaw: a comparative study of in vivo and in vitro trials

H Holtmann, J Lommen, NR Kübler… - Journal of …, 2018 - journals.sagepub.com
Objective This study was performed to determine whether the results of prevailing in vivo
and in vitro studies offer a reliable model for investigation of medication-related …

Bisphosphonate-related osteonecrosis induced change in alveolar bone architecture in rats with participation of Wnt signaling

VC de Sousa Ferreira, AP Lopes, NM Alves… - Clinical Oral …, 2021 - Springer
Objective This work aimed to study the role of inflammation in medication-related
osteonecrosis of the jaw (MRONJ) in rats with focus on Wnt signaling. Methods A total of 36 …

Adipose-derived stem cells and platelet-rich plasma for preventive treatment of bisphosphonate-related osteonecrosis of the jaw in a murine model

P Barba-Recreo, T Georgiev-Hristov… - Journal of Cranio …, 2015 - Elsevier
Objectives The main challenge in treating bisphosphonate-related osteonecrosis of the jaw
(BRONJ) is the absence of an effective established treatment. We aimed to compare …

Atorvastatin reduces zoledronic acid-induced osteonecrosis of the jaws of rats

VC de Sousa, FRN Sousa, RF Vasconcelos… - Bone, 2022 - Elsevier
The aim of this study was to evaluate the effect of Atorvastatin on Bisphosphonate-induced
osteonecrosis of the jaws of rats. Wistar rats were divided into 4 groups: Saline, Zoledronic …