The management of orofacial pain to alleviate the quality of life of affected patients is
becoming increasingly challenging for scientific research and healthcare professionals …

Peripheral neuropathy is one of the most common complications of both type 1 and type 2
diabetes. Up to half of patients with diabetes develop neuropathy during the course of their …

Nerve injury leads to chronic pain and exaggerated sensitivity to gentle touch (allodynia) as
well as a loss of sensation in the areas in which injured and non-injured nerves come …

The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Hip and knee osteoarthritis (OA) are leading causes of global disability. Most research to
date has focused on the knee, with results often extrapolated to the hip, and this extends to …

Spinal cord injury (SCI) is a devastating condition that causes severe loss of motor, sensory
and autonomic functions. Additionally, many individuals experience chronic neuropathic …

Central sensitization caused by spinal disinhibition is a key mechanism of mechanical
allodynia in neuropathic pain. However, the molecular mechanisms underlying spinal …

Background Neuroinflammation in spinal dorsal horn (SDH) plays an important role in the
pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS). Mesenchymal stem cell …

Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with
diabetes. The mechanisms mediating DNP are not completely elucidated, and effective …